IRIS

Cumene

CASRN 98-82-8 | DTXSID1021827

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (22 pp, 155 K) Last Updated: 08/01/1997

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Urinary 1 x 10 -1 Increased average kidney weight in female rats NOAEL : 1.10 x 102
mg/kg-day
1000 Low

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (22 pp, 155 K) Last Updated: 08/01/1997

System RfC (mg/m3) Basis PoD Composite UF Confidence
Endocrine, Urinary 4 x 10 -1 Increased kidney weights in female rats and adrenal weights in male and female rats NOAEL (HEC): 4.35 x 102
mg/m3
1000 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (22 pp, 155 K) Last Updated: 08/01/1997

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Carcinogenic potential cannot be determined Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)
Basis:
  • Under the proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), it is concluded that the carcinogenic potential of cumene cannot be determined because no adequate data, such as well-conducted long-term animal studies or reliable human epidemiological studies, are available for any assessment.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (22 pp, 155 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (22 pp, 155 K)

Not assessed under the IRIS Program.


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