Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) CASRN 121-82-4 | IRIS

IRIS

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

CASRN 121-82-4 | DTXSID9024142

Toxicological Review (PDF) (187 pp, 2.6 M)
IRIS Executive Summary (PDF) (7 pp, 896 K)
Supplemental Information on the IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (7 pp, 896 K) Last Updated: 08/30/2018

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Nervous	4 x 10 ^-3	Convulsions in F344 rats	BMDL₀₅ (HED): 1.3 mg/kg-day	300	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (7 pp, 896 K) Last Updated: 08/30/2018
Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (7 pp, 896 K) Last Updated: 08/30/2018

WOE Characterization	Framework for WOE Characterization
Suggestive evidence of carcinogenic potential	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is suggestive evidence of carcinogenic potential for RDX based on evidence of benign and malignant tumors in the liver and lungs of B6C3F1 mice or F344 rats.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (7 pp, 896 K)

Oral Slope Factor: 8 x 10^-2 per mg/kg-day
Extrapolation Method: Linear extrapolation from the POD (BMDL_10-HED) associated with a 10% extra cancer risk
Tumor site(s): Respiratory, Hepatic
Tumor type(s): Liver (hepatocellular adenomas or carcinomas) and lung (alveolar/bronchiolar adenomas or carcinomas) (Lish et al., 1984)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (7 pp, 896 K)

Information reviewed but value not estimated.

Organ/System-Specific RfDs

System	RfD (mg/kg-day)	Basis	PoD	UF	Confidence
Nervous	4 x 10^-3	Convulsions in F344 rats	BMDL₀₅ (HED): 1.3 mg/kg-day	300	Medium
Urinary	1 x 10^-2	Kidney medullary papillary necrosis in F344 rats	NOAEL (HED): 3.9 mg/kg-day	300	Medium
Reproductive	8 x 10^-4	Suppurative prostatitis in F344 rats	BMDL₁₀ (HED): 2.3 x 10^-1 mg/kg-day	300	Low

Aug 2018: IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Final Report) (Report)

Aug 2018: IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Discussion Draft) (Report)

Sep 2016: IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (External Review Draft) (Report)

Mar 2016: IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Public Comment Draft) (Report)

Sep 2014: IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Consultation Draft) (Report)

Aug 2013: IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Preliminary Assessment Materials) (Report)

Jul 1987: Health Effects Assessment for Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Report)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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