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Glycidaldehyde

CASRN 765-34-4 | DTXSID9020665

  • IRIS Summary (PDF) (15 pp, 121 K)

On this page:

  • Key IRIS
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (15 pp, 121 K) Last Updated: 08/22/1988

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Endocrine, Urinary, Hematologic, Other 4 x 10 -4 Weight gain retardation, enlarged adrenals, hydropic renal pelvis and hematopoietic effects NOAEL : 1.09
mg/kg-day
3000 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (15 pp, 121 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (15 pp, 121 K) Last Updated: 08/01/1991

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Based on no human data and an increased incidence of malignant tumors in rats and mice following subcutaneous injection of glycidaldehyde and of skin carcinomas following dermal application to mice. Glycidaldehyde shows mutagenic activity in many assay systems and is known to be highly reactive because of the epoxide and the aldehyde groups. A number of structurally related epoxide compounds are also carcinogenic in experimental animals, including the analogues glycidol and propylene oxide.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (15 pp, 121 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (15 pp, 121 K)

Not assessed under the IRIS Program.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Glycidaldehyde
  • eChemPortal - Glycidaldehyde

Critical Effects

Endocrine
Endocrine

Hematologic
Hematologic

Urinary
Urinary

Chemical Structure

Glycidaldehyde

Synonyms

  • Epihydrinaldehyde
  • Epihydrine aldehyde
  • Formyloxiran
  • Glycidal
  • Glycidaldehyde
  • Glycidyaldehyde
  • Glycidylaldehyde
  • Oxirane-carboxaldehyde
  • Propionaldehyde, 2,3-epoxy-
  • RCRA Waste Number U126
  • UN 2622
  • 2,3-Epoxy-1-propanal
  • 2,3-Epoxypropanal
  • 2,3-Epoxypropionaldehyde
  • 765-34-4
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