Tributyltin oxide (TBTO) CASRN 56-35-9 | IRIS

IRIS

Toxicological Review (PDF) (50 pp, 227 K)
IRIS Summary (PDF) (33 pp, 205 K)
Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Immune	3 x 10 ^-4	Immunosuppression	BMD ₁₀ : 3 x 10^-2 mg/kg-day	100	High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (33 pp, 205 K) Last Updated: 09/01/1997
Information reviewed but value not estimated.

Weight of Evidence for Cancer (PDF) (33 pp, 205 K) Last Updated: 09/01/1997

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Carcinogenic potential cannot be determined	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

There are no data in humans concerning development of cancer following exposure to tributyltin oxide (TBTO). Cancer bioassays following oral exposure have been conducted in rats and mice. Because of the questionable data from the bioassay in rats, EPA assigns TBTO to the "cannot be determined" category [U.S. EPA, 1996 (proposed)].
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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