IRIS

Aniline

CASRN 62-53-3 | DTXSID8020090

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (19 pp, 139 K) Last Updated:
Not assessed under the IRIS Program.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (19 pp, 139 K) Last Updated: 11/01/1990

System RfC (mg/m3) Basis PoD Composite UF Confidence
Hematologic 1 x 10 -3 Methemoglobin increase, spleen toxicity NOAEL (HEC): 3.4
mg/m3
3000 Low

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (19 pp, 139 K) Last Updated: 09/07/1988

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Induction of tumors of the spleen and the body cavity in two strains of rat, and some supporting genetic toxicological evidence.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (19 pp, 139 K)

Oral Slope Factor: 5.7 x 10-3 per mg/kg-day
Drinking Water Unit Risk: 1.6 x 10-7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Immune
Tumor type(s): Spleen, combined fibrosarcoma, stromal sarcoma, capsular sarcoma and hemangiosarcoma (CIIT, 1982)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (19 pp, 139 K)

Not Assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

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