Aniline
CASRN 62-53-3 | DTXSID8020090
- IRIS Summary (PDF) (19 pp, 139 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (19 pp, 139 K) Last Updated:
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF) (19 pp, 139 K) Last Updated: 11/01/1990
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hematologic | 1 x 10 -3 | Methemoglobin increase, spleen toxicity |
NOAEL
(HEC):
3.4
mg/m3 |
3000 | Low |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(19 pp, 139 K)
Last Updated: 09/07/1988
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Induction of tumors of the spleen and the body cavity in two strains of rat, and some supporting genetic toxicological evidence.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (19 pp, 139 K)
Oral Slope Factor:
5.7
x 10-3
per mg/kg-day
Drinking Water Unit Risk:
1.6
x 10-7
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Immune
Tumor type(s): Spleen, combined fibrosarcoma, stromal sarcoma, capsular sarcoma and hemangiosarcoma (CIIT, 1982)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (19 pp, 139 K)
Not Assessed under the IRIS Program.
Chemical Documents
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Related Links
Critical Effects
Tumor Sites
Chemical Structure
Synonyms
- Aminobenzene
- Aminophen
- Aniline
- Aniline-oil
- Kyanol
- Phenylamine
- 62-53-3