IRIS

1,2-Dibromoethane

CASRN 106-93-4 | DTXSID3020415

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (34 pp, 241 K) Last Updated: 07/29/2004

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (34 pp, 241 K) Last Updated: 07/29/2004

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (34 pp, 241 K) Last Updated: 07/29/2004

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999)
Basis:
  • Under the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), 2-dibromoethane is considered "likely to be carcinogenic to humans" based on strong evidence of carcinogenicity in animals and inconclusive evidence of carcinogenicity in an exposed human population.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (34 pp, 241 K)

Oral Slope Factor: 2 per mg/kg-day (95% upper bound)
Drinking Water Unit Risk: 6 x 10-5 per µg/L x 10 (95% upper bound)
Extrapolation Method: Multistage model with Poly-3 adjusted incidence data linear extrapolation from lower 95% confidence limit on dose associated with extra risk (adjusted for background) at point of departure at lower end of data range.
Tumor site(s): Gastrointestinal, Endocrine, Other
Tumor type(s): Forestomach tumors, hemangiosarcomas, thyroid follicular cell adenomas or carcinomas (NCI, 1978)

Oral Slope Factor: 1 mg/kg-day (central tendency estimate)
Extrapolation Method: Multistage model with Poly-3 adjusted incidence data central tendency estimate
Tumor site(s): Gastrointestinal, Endocrine, Other
Tumor type(s): Forestomach tumors, hemangiosarcomas, thyroid follicular cell adenomas or carcinomas (NCI, 1978)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (34 pp, 241 K)

Inhalation Unit Risk: 6 x 10-4 per µg/m3 (95% upper bound)
Extrapolation Method: Multistage-Weibull model linear extrapolation from lower 95% confidence limit on dose associated with extra risk (adjusted for background) at point of departure at lower end of data range.
Tumor site(s): Reproductive, Respiratory, Other
Tumor type(s): Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas (NTP, 1982)

Inhalation Unit Risk: 3 x 10-4 per µg/m3 (central tendency estimate)
Extrapolation Method: Multistage model with Poly-3 adjusted incidence data central tendency estimate
Tumor site(s): Reproductive, Respiratory, Other
Tumor type(s): Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomas (NTP, 1982)

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