Dimethyl sulfate
CASRN 77-78-1 | DTXSID5024055
- IRIS Summary (PDF) (10 pp, 100 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (10 pp, 100 K) Last Updated:
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF) (10 pp, 100 K) Last Updated: 01/01/1992
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(10 pp, 100 K)
Last Updated: 09/07/1988
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Classification is based on induction of local carcinomas following inhalation and subcutaneous exposures in rats, tumor induction in rats following prenatal exposure, and evidence suggestive of carcinogenicity in hamsters and mice by inhalation. Dimethyl sulfate alkylates cellular macromolecules and is genotoxic.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (10 pp, 100 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (10 pp, 100 K)
Not assessed under the IRIS Program.
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Chemical Structure
Synonyms
- DMS
- Dimethyl monosulfate
- Dimethyl sulfate
- Methyl sulfate
- 77-78-1