IRIS

N-Nitroso-di-n-butylamine

CASRN 924-16-3 | DTXSID2021026

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (10 pp, 101 K) Last Updated:
Not assessed under the IRIS Program.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (10 pp, 101 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (10 pp, 101 K) Last Updated: 01/31/1987

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Increased incidences of several tumor types in rats, mice, and hamsters exposed by various routes.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (10 pp, 101 K)

Oral Slope Factor: 5.4 per mg/kg-day
Drinking Water Unit Risk: 1.6 x 10-4 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Urinary, Gastrointestinal
Tumor type(s): Bladder and esophagus tumors (Bertram and Craig, 1970)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (10 pp, 101 K)

Inhalation Unit Risk: 1.6 x 10-3 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal, Urinary
Tumor type(s): Bladder and esophagus tumors (Bertram and Craig, 1970)


Additional EPA toxicity information may be available by visiting the following sites:

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