Manganese
CASRN 7439-96-5 | DTXSID2024169
- IRIS Summary (PDF) (48 pp, 265 K)
- Status: Manganese is in step 1 at this time; see Quick Check.
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(48 pp, 265 K)
Last Updated: 11/01/1995
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous | 1.4 x 10 -1 | CNS effects |
NOAEL
:
1.4
x 10-1 mg/kg-day |
1 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(48 pp, 265 K)
Last Updated: 12/01/1993
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous | 5 x 10 -5 | Impairment of neurobehavioral function |
LOAEL
(HEC):
5
x 10-2 mg/m3 |
1000 | Medium |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(48 pp, 265 K)
Last Updated: 09/26/1988
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Existing studies are inadequate to assess the carcinogenicity of manganese.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (48 pp, 265 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (48 pp, 265 K)
Not assessed under the IRIS Program.
Program Outlook Details
| Public Assessment Materials | Date |
|---|---|
| Problem Formulation Materials/IRIS Assessment Plan | TBD |
| Preliminary Assessment Materials/Systematic Review Protocol | TBD |
| Public Comment | TBD |
| External Peer Review | TBD |
| Post Final Assessment | TBD |
Note: Any future dates displayed in the table above should be considered estimates and are subject to change. Once the external peer review is complete, estimated dates for release of the final assessment will be published. For the latest information on the status of this assessment, please refer to the IRIS Program Outlook. To access assessment documents, meeting materials or other supporting documents related to this assessment, visit the Chemical Documents tab. For more information about the development process, visit the IRIS Process page.
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.
Contact Us to ask a question, provide feedback or report a problem.
