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Bis(chloromethyl)ether (BCME)

CASRN 542-88-1 | DTXSID8020173

  • IRIS Summary (PDF) (12 pp, 113 K)

On this page:

  • Key IRIS
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 113 K) Last Updated:

Not assessed under the IRIS Program.


Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 113 K) Last Updated: 07/01/1991

Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (12 pp, 113 K) Last Updated: 09/26/1988

WOE Characterization Framework for WOE Characterization
A (Human carcinogen) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Statistically significant increases in lung tumors (oat cell carcinomas) observed in six studies of exposed workers and bioassay data from rats and mice.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 113 K)

Oral Slope Factor: 2.2 x 102 per mg/kg-day
Drinking Water Unit Risk: 6.2 x 10-3 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Respiratory tract tumors (Kuschner et al., 1975)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 113 K)

Inhalation Unit Risk: 6.2 x 10-2 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Respiratory tract tumors (Kuschner et al., 1975)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Bis(chloromethyl)ether (BCME)
  • eChemPortal - Bis(chloromethyl)ether (BCME)

Tumor Sites

Respiratory
Respiratory

Chemical Structure

Bis(chloromethyl)ether (BCME)

Synonyms

  • BCME
  • Bis(chloromethyl)ether
  • Bis(chloromethyl)ether (BCME)
  • Bis-CME
  • Chloro(chloromethoxy)methane
  • Chloromethyl ether
  • Dichlordimethylaether
  • Dimethyl-1,1'-dichloroether
  • Ether, bis(chloromethyl)
  • Methane, oxybis(chloro-
  • Oxybis(chloromethane)
  • RCRA Waste Number p016
  • UN 2249
  • sym-Dichloro-dimethyl ether
  • sym-Dichloromethyl ether
  • 1,1'-Dichlorodimethyl ether
  • 542-88-1
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