2,4-/2,6-Dinitrotoluene mixture
CASRN Various | DTXSID9024069
- IRIS Summary (PDF) (12 pp, 110 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(12 pp, 110 K)
Last Updated:
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(12 pp, 110 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(12 pp, 110 K)
Last Updated: 09/01/1990
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Based on multiple benign and malignant tumor types at multiple sites in both sexes of rats (2 strains) and malignant renal tumors in male mice. The classification is supported by evidence of mutagenicity.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 110 K)
Oral Slope Factor:
6.8
x 10-1
per mg/kg-day
Drinking Water Unit Risk:
1.9
x 10-5
per µg/L
Extrapolation Method: Linearized multistage procedure
Tumor site(s): Reproductive, Hepatic
Tumor type(s): Liver: hepatocellular carcinomas, neoplastic nodules; mammary gland: adenomas, fibroadenomas, fibromas, adenocarcinomas/ carcinomas (Ellis et al., 1979)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 110 K)
Not Assessed under the IRIS Program.
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