IRIS

Nitroguanidine

CASRN 556-88-7 | DTXSID4024222

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (11 pp, 107 K) Last Updated: 09/01/1989

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Developmental, Other 1 x 10 -1 Reduced weight gain in female rats, maternal/ fetal toxicity in rats, and equivocal evidence of developmental toxicity in rabbits NOAEL : 3.16 x 102
mg/kg-day
3000 Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (11 pp, 107 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (11 pp, 107 K) Last Updated: 09/01/1990

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Pertinent data regarding carcinogenicity have not been located in the available literature.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (11 pp, 107 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (11 pp, 107 K)

Not assessed under the IRIS Program.


Additional EPA toxicity information may be available by visiting the following sites:

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