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Zinc and Compounds

CASRN 7440-66-6 | DTXSID7035012

  • Toxicological Review (PDF) (83 pp, 520 K)
  • IRIS Summary (PDF) (21 pp, 154 K)

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (21 pp, 154 K) Last Updated: 08/03/2005

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Immune, Hematologic 3 x 10 -1 Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and female volunteers LOAEL : 0.91
mg/kg-day
3 Medium/High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (21 pp, 154 K) Last Updated: 08/03/2005

Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (21 pp, 154 K) Last Updated: 08/03/2005

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Data are inadequate for an assessment of human carcinogenic potential Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999)
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is inadequate information to assess carcinogenic potential of zinc, because studies of humans occupationally-exposed to zinc are inadequate or inconclusive, adequate animal bioassays of the possible carcinogenicity of zinc are not available, and results of genotoxic tests of zinc have been equivocal.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (21 pp, 154 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (21 pp, 154 K)

Not assessed under the IRIS Program.

Chemical Documents

Apr 2003: IRIS Toxicological Review and Summary Documents For Zinc and Compounds (External Review Draft) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Zinc and Compounds
  • eChemPortal - Zinc and Compounds

Critical Effects

Hematologic
Hematologic

Immune
Immune

Chemical Structure

Zinc and Compounds

Synonyms

  • Asarco l 15
  • Blue powder
  • Cinc [Spanish]
  • Emanay zinc dust
  • Granular zinc
  • HSDB 1344
  • Jasad
  • Lead refinery vacuum zinc
  • Merrillite
  • UN 1436
  • Zinc
  • Zinc
  • Zinc and Compounds
  • Zinc dust
  • Zinc powder
  • Zinc, ashes
  • Zinc, powder or dust, non-pyrophoric
  • Zinc, powder or dust, pyrophoric
  • 7440-66-6
  • IRIS Home
  • About IRIS
  • IRIS Recent Additions
  • IRIS Calendar
  • IRIS Assessments
  • Advanced Search
  • IRIS Program Materials
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