Zinc and Compounds

CASRN 7440-66-6 | DTXSID7035012

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Immune, Hematologic	3 x 10 ^-1	Decreases in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity in healthy adult male and female volunteers	LOAEL : 0.91 mg/kg-day	3	Medium/High

Information reviewed but value not estimated.

Weight of Evidence for Cancer (PDF) (21 pp, 154 K) Last Updated: 08/03/2005

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Data are inadequate for an assessment of human carcinogenic potential	Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999)
Inadequate information to assess carcinogenic potential	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is inadequate information to assess carcinogenic potential of zinc, because studies of humans occupationally-exposed to zinc are inadequate or inconclusive, adequate animal bioassays of the possible carcinogenicity of zinc are not available, and results of genotoxic tests of zinc have been equivocal.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.