Crotonaldehyde CASRN 123-73-9 | IRIS

IRIS

Reference Dose for Oral Exposure (RfD) (PDF) (8 pp, 101 K) Last Updated:
Not assessed under the IRIS Program.

Weight of Evidence for Cancer (PDF) (8 pp, 101 K) Last Updated: 06/01/1991

WOE Characterization	Framework for WOE Characterization
C (Possible human carcinogen)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Based on no human data and an increased incidence of hepatocellular carcinomas and hepatic neoplastic nodules (combined) in male F344 rats. The possible carcinogenicity of crotonaldehyde is supported by genotoxic activity and the expected reactivity of croton oil and aldehyde. Crotonaldehyde is also a suspected metabolite of N-nitrosopyrrolidine, a probable human carcinogen.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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