Dinoseb
CASRN 88-85-7 | DTXSID3020207
- IRIS Summary (PDF) (12 pp, 111 K)
- Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(12 pp, 111 K)
Last Updated: 01/31/1987
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 1 x 10 -3 | Decreased fetal weight |
LEL
:
1
mg/kg-day |
1000 | Low |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(12 pp, 111 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(12 pp, 111 K)
Last Updated: 08/01/1989
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Dinoseb was not observed to be carcinogenic in two inadequate studies in rats and in mice. In a third study, an increase in benign liver tumors in female mice was not considered to be treatment-related. The increase was much lower in the high dose than the mid dose, there were no decreases in time to tumor, nor any evidence of any of the potentially predisposing lesions in the liver such as hypertrophy, hyperplasia or degeneration which are often associated with known hepatocellular carcinogens.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 111 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 111 K)
Not assessed under the IRIS Program.
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
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