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Phosgene

CASRN 75-44-5 | DTXSID0024260

  • Toxicological Review (PDF) (102 pp, 614 K)
  • IRIS Summary (PDF) (22 pp, 166 K)

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (22 pp, 166 K) Last Updated: 01/31/2006

Information reviewed but value not estimated.


Reference Concentration for Inhalation Exposure (RfC) (PDF) (22 pp, 166 K) Last Updated: 01/31/2006

System RfC (mg/m3) Basis PoD Composite UF Confidence
Respiratory 3 x 10 -4 Collagen staining indicative of fibrosis BMDL 10 (HEC): 3 x 10-2
mg/m3
100 Medium

Cancer Assessment

Weight of Evidence for Cancer (PDF) (22 pp, 166 K) Last Updated: 01/31/2006

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), there is inadequate information to assess carcinogenic potential of phosgene. A single epidemiology study was not considered adequate for evaluating carcinogenic potential in humans, and no animal cancer bioassays of phosgene have been conducted.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (22 pp, 166 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (22 pp, 166 K)

Not assessed under the IRIS Program.

Chemical Documents

Apr 2004: IRIS Toxicological Review of Phosgene (External Review Draft) (Report)

Sep 2001: IRIS Toxicological Review of Phosgene (Final Report) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Phosgene
  • eChemPortal - Phosgene

Critical Effects

Respiratory
Respiratory

Chemical Structure

Phosgene

Synonyms

  • CG
  • Carbon Dichloride Oxide
  • Carbon oxychloride
  • Carbone (oxychlorure de) [French]
  • Carbonic dichloride
  • Carbonio (ossicloruro di) [Italian]
  • Carbonyl chloride
  • Carbonyl dichloride
  • Carbonylchlorid [German]
  • Chloroformyl chloride
  • Fosgeen [Dutch]
  • Fosgen [Polish]
  • Fosgene [Italian]
  • Fosgeno [Spanish]
  • HSDB 796
  • Koolstofoxychloride [Dutch]
  • NCI-C60219
  • Phosgen [German]
  • Phosgene
  • RCRA Waste Number P095
  • 75-44-5
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