Phosgene CASRN 75-44-5 | IRIS

IRIS

Reference Dose for Oral Exposure (RfD) (PDF) (22 pp, 166 K) Last Updated: 01/31/2006
Information reviewed but value not estimated.

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Respiratory	3 x 10 ^-4	Collagen staining indicative of fibrosis	BMDL ₁₀ (HEC): 3 x 10^-2 mg/m³	100	Medium

Weight of Evidence for Cancer (PDF) (22 pp, 166 K) Last Updated: 01/31/2006

WOE Characterization	Framework for WOE Characterization
Inadequate information to assess carcinogenic potential	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), there is inadequate information to assess carcinogenic potential of phosgene. A single epidemiology study was not considered adequate for evaluating carcinogenic potential in humans, and no animal cancer bioassays of phosgene have been conducted.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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