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Epichlorohydrin

CASRN 106-89-8 | DTXSID1020566

  • IRIS Summary (PDF) (24 pp, 167 K)

On this page:

  • Key IRIS
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (24 pp, 167 K) Last Updated: 04/01/1992

Information reviewed but value not estimated.


Reference Concentration for Inhalation Exposure (RfC) (PDF) (24 pp, 167 K) Last Updated: 04/01/1992

System RfC (mg/m3) Basis PoD Composite UF Confidence
Respiratory 1 x 10 -3 Changes in the nasal turbinates NOAEL (HEC): 3.6 x 10-1
mg/m3
300 Medium

Cancer Assessment

Weight of Evidence for Cancer (PDF) (24 pp, 167 K) Last Updated: 03/01/1988

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Human data are inadequate. Multiple studies in rats and mice administered epichlorohydrin by various routes were positive. As epichlorohydrin is a strong alkylating agent, tumors are produced at the site of application.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (24 pp, 167 K)

Oral Slope Factor: 9.9 x 10-3 per mg/kg-day
Drinking Water Unit Risk: 2.8 x 10-7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Papillomas and carcinomas of the forestomach (Konishi et al., 1980)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (24 pp, 167 K)

Inhalation Unit Risk: 1.2 x 10-6 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Nasal cavity tumors (Laskin et al., 1980)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Epichlorohydrin
  • eChemPortal - Epichlorohydrin

Critical Effects

Respiratory
Respiratory

Tumor Sites

Gastrointestinal
Gastrointestinal

Respiratory
Respiratory

Chemical Structure

Epichlorohydrin

Synonyms

  • Chloromethyloxirane
  • Epichlorhydrin
  • Epichlorohydrin
  • y-Chloropropyleneoxide
  • 1-Chlor-2,3-epoxypropane
  • 106-89-8
  • 2-Chloropropylene oxide
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