Epichlorohydrin CASRN 106-89-8 | IRIS

IRIS

Epichlorohydrin

CASRN 106-89-8 | DTXSID1020566

IRIS Summary (PDF) (24 pp, 167 K)

Key IRIS
Values
Other EPA
Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (24 pp, 167 K) Last Updated: 04/01/1992
Information reviewed but value not estimated.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (24 pp, 167 K) Last Updated: 04/01/1992

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Respiratory	1 x 10 ^-3	Changes in the nasal turbinates	NOAEL (HEC): 3.6 x 10^-1 mg/m³	300	Medium

Cancer Assessment

Weight of Evidence for Cancer (PDF) (24 pp, 167 K) Last Updated: 03/01/1988

WOE Characterization	Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Human data are inadequate. Multiple studies in rats and mice administered epichlorohydrin by various routes were positive. As epichlorohydrin is a strong alkylating agent, tumors are produced at the site of application.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (24 pp, 167 K)

Oral Slope Factor: 9.9 x 10^-3 per mg/kg-day
Drinking Water Unit Risk: 2.8 x 10^-7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Papillomas and carcinomas of the forestomach (Konishi et al., 1980)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (24 pp, 167 K)

Inhalation Unit Risk: 1.2 x 10^-6 per µg/m³
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Nasal cavity tumors (Laskin et al., 1980)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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