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Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)

CASRN 111-76-2 | DTXSID1024097

  • Toxicological Review (PDF) (206 pp, 3.65 M)
  • IRIS Summary (PDF) (31 pp, 297 K)

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (31 pp, 297 K) Last Updated: 03/31/2010

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hematologic 1 x 10 -1 Hemosiderin deposition in the liver BMDL (HED): 1.4
mg/kg-day
10 Medium/High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (31 pp, 297 K) Last Updated: 03/31/2010

System RfC (mg/m3) Basis PoD Composite UF Confidence
Hematologic 1.6 Hemosiderin deposition in the liver BMCL (HEC): 16
mg/m3
10 Medium/High

Cancer Assessment

Weight of Evidence for Cancer (PDF) (31 pp, 297 K) Last Updated: 03/31/2010

WOE Characterization Framework for WOE Characterization
Not likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), EGBE is deemed "not likely to be carcinogenic to humans" at environmental concentrations at or below the RfD and RfC, based on laboratory animal evidence, mode-of-action information, and limited human study information.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (31 pp, 297 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (31 pp, 297 K)

Not assessed under the IRIS Program.

Chemical Documents

Mar 2010: IRIS Toxicological Review of Ethylene Glycol Mono Butyl Ether (EGBE) (Final Report) (Report)

Nov 2009: IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (Interagency Science Discussion Draft) (Report)

Apr 2008: IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (External Review Draft) (Report)

Jul 2005: An Evaluation of the Human Carcinogenic Potential of Ethylene Glycol Butyl Ether (EGBE) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)
  • eChemPortal - Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)

Critical Effects

Hematologic
Hematologic

Chemical Structure

Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)

Synonyms

  • Bucs
  • Butoxyethanol
  • Butyl Cellosolve
  • Butyl Glycol
  • Butyl Oxitol
  • CASRN -- 111-76-2
  • Dowanol EB
  • Ektasolve EB
  • Ethylene Glycol N-Butyl
  • Ethylene glycol monobutyl ether (EGBE)
  • Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)
  • Gafcol EB
  • Glycol Butyl Ether
  • Glycol Ether EB
  • Glycol Ether EB Acetate
  • Glycol Monobutyl Ether
  • Jeffersol EB
  • Monobutyl Ether Of Ethylene Glycol
  • Monobutyl Glycol Ether
  • N-Butoxyethanol
  • O-Butyl Ethylene Glycol
  • Poly-Solv EB
  • 2-Butoxy-1-Ethanol
  • 2-Butoxyethanol
  • 3-Oxa-1-Heptanol
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