Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)
CASRN 111-76-2 | DTXSID1024097
- Toxicological Review (PDF) (206 pp, 3.65 M)
- IRIS Summary (PDF) (31 pp, 297 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (31 pp, 297 K) Last Updated: 03/31/2010
System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
---|---|---|---|---|---|
Hematologic | 1 x 10 -1 | Hemosiderin deposition in the liver |
BMDL
(HED):
1.4
mg/kg-day |
10 | Medium/High |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (31 pp, 297 K) Last Updated: 03/31/2010
System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
---|---|---|---|---|---|
Hematologic | 1.6 | Hemosiderin deposition in the liver |
BMCL
(HEC):
16
mg/m3 |
10 | Medium/High |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(31 pp, 297 K)
Last Updated: 03/31/2010
WOE Characterization | Framework for WOE Characterization |
---|---|
Not likely to be carcinogenic to humans | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), EGBE is deemed "not likely to be carcinogenic to humans" at environmental concentrations at or below the RfD and RfC, based on laboratory animal evidence, mode-of-action information, and limited human study information.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (31 pp, 297 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (31 pp, 297 K)
Not assessed under the IRIS Program.
Chemical Documents
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Related Links
Critical Effects
Chemical Structure
Synonyms
- Bucs
- Butoxyethanol
- Butyl Cellosolve
- Butyl Glycol
- Butyl Oxitol
- CASRN -- 111-76-2
- Dowanol EB
- Ektasolve EB
- Ethylene Glycol N-Butyl
- Ethylene glycol monobutyl ether (EGBE)
- Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)
- Gafcol EB
- Glycol Butyl Ether
- Glycol Ether EB
- Glycol Ether EB Acetate
- Glycol Monobutyl Ether
- Jeffersol EB
- Monobutyl Ether Of Ethylene Glycol
- Monobutyl Glycol Ether
- N-Butoxyethanol
- O-Butyl Ethylene Glycol
- Poly-Solv EB
- 2-Butoxy-1-Ethanol
- 2-Butoxyethanol
- 3-Oxa-1-Heptanol