Ethylbenzene

CASRN 100-41-4 | DTXSID3020596

IRIS Summary (PDF) (21 pp, 148 K)
Status: Ethylbenzene is in step 1 at this time; see Quick Check.

On this page:

Key IRIS
Values
Assessment
Status
Chemical
Documents
Other EPA
Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (21 pp, 148 K) Last Updated: 01/31/1987

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Hepatic, Urinary	1 x 10 ^-1	Liver and kidney toxicity	NOEL : 9.71 x 10¹ mg/kg-day	1000	Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (21 pp, 148 K) Last Updated: 03/01/1991

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Developmental	1	Developmental toxicity	NOAEL (HEC): 4.34 x 10² mg/m³	300	Low

Cancer Assessment

Weight of Evidence for Cancer (PDF) (21 pp, 148 K) Last Updated: 09/17/1988

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Nonclassifiable due to lack of animal bioassays and human studies.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (21 pp, 148 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (21 pp, 148 K)

Not assessed under the IRIS Program.

Program Outlook Details

Public Assessment Materials	Date
Problem Formulation Materials/IRIS Assessment Plan	Sep-2017
Preliminary Assessment Materials/Systematic Review Protocol	Feb-2023
Public Comment	TBD
External Peer Review	TBD
Post Final Assessment	TBD

Note: Any future dates displayed in the table above should be considered estimates and are subject to change. Once the external peer review is complete, estimated dates for release of the final assessment will be published. For the latest information on the status of this assessment, please refer to the IRIS Program Outlook. To access assessment documents, meeting materials or other supporting documents related to this assessment, see the list of Chemical Documents. For more information about the development process, visit the IRIS Process page.

Chemical Documents

Feb 2023: Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials) (Report)

Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

Sep 2017: IRIS Assessment Plan for Ethylbenzene (Scoping and Problem Formulation Materials) (Report)

Jul 2014: IRIS Toxicological Review of Ethylbenzene (Scoping and Problem Formulation Materials) (Report)

Mar 1985: Drinking Water Criteria Document For Ethylbenzene (Final Draft, 1985) (Report)

Sep 1984: Health Effects Assessment for Ethylbenzene (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.