IRIS

Ethylbenzene

CASRN 100-41-4 | DTXSID3020596

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (21 pp, 148 K) Last Updated: 01/31/1987

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic, Urinary 1 x 10 -1 Liver and kidney toxicity NOEL : 9.71 x 101
mg/kg-day
1000 Low

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (21 pp, 148 K) Last Updated: 03/01/1991

System RfC (mg/m3) Basis PoD Composite UF Confidence
Developmental 1 Developmental toxicity NOAEL (HEC): 4.34 x 102
mg/m3
300 Low

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (21 pp, 148 K) Last Updated: 09/17/1988

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Nonclassifiable due to lack of animal bioassays and human studies.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (21 pp, 148 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (21 pp, 148 K)

Not assessed under the IRIS Program.

Program Outlook Details

Public Assessment Materials Date
Problem Formulation Materials/IRIS Assessment Plan Sep-2017
Preliminary Assessment Materials/Systematic Review Protocol Dec-2022
Public Comment TBD
External Peer Review TBD
Post Final Assessment TBD

Note: Any future dates displayed in the table above should be considered estimates and are subject to change. Once the external peer review is complete, estimated dates for release of the final assessment will be published. For the latest information on the status of this assessment, please refer to the IRIS Program Outlook. To access assessment documents, meeting materials or other supporting documents related to this assessment, visit the Chemical Documents tab. For more information about the development process, visit the IRIS Process page.

Additional EPA toxicity information may be available by visiting the following sites:

You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.

Contact Us to ask a question, provide feedback or report a problem.

Quick Check