Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) CASRN 101-68-8 | IRIS

IRIS

Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 170 K) Last Updated:
Not assessed under the IRIS Program.

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous, Respiratory	6 x 10 ^-4	Hyperplasia of olfactory epithelium	BMC ₁₀ (HEC): 6 x 10^-2 mg/m³	100	Medium

Weight of Evidence for Cancer (PDF) (23 pp, 170 K) Last Updated: 02/07/1998

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Carcinogenic potential cannot be determined	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

Under U.S. EPA's 1996 Proposed Guidelines for Carcinogen Risk Assessment, the carcinogenic potential of MDI/PMDI would be characterized as "cannot be determined," but for which there is suggestive evidence that raises concern for carcinogenic effects.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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