Glyphosate
CASRN 1071-83-6 | DTXSID1024122
- IRIS Summary (PDF) (10 pp, 102 K)
- Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (10 pp, 102 K) Last Updated: 01/31/1987
System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
---|---|---|---|---|---|
Developmental, Urinary | 1 x 10 -1 | Increased incidence of renal tubular dilation in F3b offspring |
NOEL
:
1.0
x 101
mg/kg-day |
100 | High |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (10 pp, 102 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(10 pp, 102 K)
Last Updated: 10/01/1989
WOE Characterization | Framework for WOE Characterization |
---|---|
D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Inadequate evidence for oncogenicity in animals. Glyphosate was originally classified as C, possible human carcinogen, on the basis of increased incidence of renal tumors in mice. Following independent review of the slides the classification was changed to D on the basis of a lack of statistical significance and uncertainty as to a treatment-related effect.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (10 pp, 102 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (10 pp, 102 K)
Not assessed under the IRIS Program.
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Related Links
Critical Effects
Chemical Structure
Synonyms
- Glycine, n-(phosphonomethyl)-
- Glyphosate
- Mon 0573
- n-(Phosphonomethyl)glycine
- 1071-83-6