Hexachlorocyclopentadiene (HCCPD)

CASRN 77-47-4 | DTXSID2020688

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Gastrointestinal	6 x 10 ^-3	Chronic irritation	BMDL ₁₀ : 6 mg/kg-day	1000	Low

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Respiratory	2 x 10 ^-4	Suppurative inflammation of the nose	NOAEL (HEC): 2.4 x 10^-2 mg/m³	100	Medium

Weight of Evidence for Cancer (PDF) (25 pp, 172 K) Last Updated: 07/05/2001

WOE Characterization	Framework for WOE Characterization
E (Evidence of non-carcinogenicity for humans)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Not likely to be carcinogenic to humans	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

According to the existing Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a), evaluation of the weight-of-evidence for carcinogenicity to humans indicates that HCCPD is most appropriately categorized as Group E, Evidence of Noncarcinogenicity to Humans, via inhalation exposure. In accordance with U.S. EPA's Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), HCCPD is not likely to be a human carcinogen by the inhalation route based on current data indicating no evidence of cancer in well-conducted bioassays in two species of rodents; the absence of increased deaths from cancer in the limited human occupational studies available; and lack of mutagenicity in a variety of test systems.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.