Trichloroacetic acid CASRN 76-03-9 | IRIS

IRIS

Trichloroacetic acid

CASRN 76-03-9 | DTXSID1021378

Toxicological Review (PDF) (270 pp, 2.08 M)
IRIS Summary (PDF) (26 pp, 273 K)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (26 pp, 273 K) Last Updated: 09/30/2011

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Hepatic	2 x 10 ^-2	Hepatocellular necrosis	BMDL ₁₀ : 18 mg/kg-day	1000	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (26 pp, 273 K) Last Updated: 09/30/2011
Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (26 pp, 273 K) Last Updated: 09/30/2011

WOE Characterization	Framework for WOE Characterization
Suggestive evidence of carcinogenic potential	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under the Guidelines for Carcinogen Risk Assessment (Cancer Guidelines) (U.S. EPA, 2005a), there is suggestive evidence of carcinogenic potential for TCA based on significantly increased incidences of liver tumors in male B6C3F1 mice exposed via drinking water for 52–104 weeks (DeAngelo et al., 2008 Bull et al., 2002, 1990 Herren-Freund et al., 1987) and female B6C3F1 mice exposed for 51 or 82 weeks (Pereira, 1996), and lack of treatment-related tumors in a study of male F344/N rats following lifetime exposure in drinking water (DeAngelo et al., 1997).
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (26 pp, 273 K)

Oral Slope Factor: 7 x 10^-2 per mg/kg-day
Drinking Water Unit Risk: 2 x 10^-6 per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the POD (LED10).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (DeAngelo et al. (2008))

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (26 pp, 273 K)

Information reviewed but value not estimated.

Sep 2011: IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Final Report) (Report)

Jul 2011: IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft) (Report)

Sep 2009: IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft) (Report)

Aug 2009: IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Consultation Draft) (Report)

Mar 2007: Difficulty Of Mode Of Action Determination For Trichloroethylene: An Example Of Complex Interactions Of Metabolites And Other Chemical Exposures (Journal Article) (Journal)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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