IRIS

Perfluorobutanoic Acid (PFBA)

CASRN 375-22-4 | DTXSID4059916

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (6 pp, 364 K) Last Updated: 12/22/2022

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Endocrine, Hepatic 1 x 10 -3 Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) NOAEL (HED): 1.27
mg/kg-day
1000 Medium

 


System RfC (mg/m3) Basis PoD Composite UF Confidence

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (6 pp, 364 K) Last Updated: 12/22/2022
Information reviewed but value not estimated.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (6 pp, 364 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (6 pp, 364 K)

Not assessed under the IRIS Program.

Organ/System-Specific RfDs

System RfD (mg/kg-day) Basis PoD UF Confidence
Endocrine, Hepatic 1 x 10-3 Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) NOAEL (HED): 1.27
mg/kg-day
1000 Medium
Hepatic 1 x 10-3 Increased hepatocellular hypertrophy NOAEL (HED): 1.27
mg/kg-day
1000 Medium
Developmental 6 x 10-3 Developmental delays BMDL (HED): 6.2 x 10-1
mg/kg-day
100 Low/Medium

 

Additional EPA toxicity information may be available by visiting the following sites:

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