Perfluorobutanoic Acid (PFBA) CASRN 375-22-4 | IRIS | US EPA, ORD

IRIS

Perfluorobutanoic Acid (PFBA)

CASRN 375-22-4 | DTXSID4059916

Toxicological Review (PDF) (146 pp, 2.86 M)
IRIS Executive Summary (PDF) (6 pp, 364 K)
Supplemental Information on the IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (6 pp, 364 K) Last Updated: 12/22/2022

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Endocrine, Hepatic	1 x 10 ^-3	Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid)	NOAEL (HED): 1.27 mg/kg-day	1000	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (6 pp, 364 K)

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence

Cancer Assessment

Weight of Evidence for Cancer (PDF) (6 pp, 364 K) Last Updated: 12/22/2022
Information reviewed but value not estimated.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (6 pp, 364 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (6 pp, 364 K)

Not assessed under the IRIS Program.

Organ/System-Specific RfDs

System	RfD (mg/kg-day)	Basis	PoD	UF	Confidence
Endocrine, Hepatic	1 x 10^-3	Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid)	NOAEL (HED): 1.27 mg/kg-day	1000	Medium
Hepatic	1 x 10^-3	Increased hepatocellular hypertrophy	NOAEL (HED): 1.27 mg/kg-day	1000	Medium
Developmental	6 x 10^-3	Developmental delays	BMDL (HED): 6.2 x 10^-1 mg/kg-day	100	Low/Medium

Jun 2023: External Peer Review Activities for PFDA Integrated Risk Information System (IRIS) Assessment (2023) (Other)

Dec 2022: IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Final Report, 2022) (Report)

Nov 2022: IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Interagency Science Discussion Draft Comments, 2022) (Other)

Oct 2021: External Peer Review Activities for PFBA Integrated Risk Information System (IRIS) Assessment (Nov 2021) (Other)

Aug 2021: IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Public Comment and External Review Draft, 2021) (Report)

Aug 2020: Toxicological Review of Perfluorobutanoic Acid and Related Compound Ammonium Perfluorobutanoic Acid (PFBA) (Interagency Science Consultation Draft, 2020) (Report)

Nov 2019: Systematic Review Protocol for the Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid IRIS Assessment (Preliminary Assessment Materials, 2019) (Report)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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