Perfluorobutanoic Acid (PFBA) CASRN 375-22-4 | IRIS

IRIS

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Endocrine, Hepatic	1 x 10 ^-3	Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid)	NOAEL (HED): 1.27 mg/kg-day	1000	Medium

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence

Weight of Evidence for Cancer (PDF) (6 pp, 364 K) Last Updated: 12/22/2022
Information reviewed but value not estimated.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

System	RfD (mg/kg-day)	Basis	PoD	UF	Confidence
Endocrine, Hepatic	1 x 10^-3	Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid)	NOAEL (HED): 1.27 mg/kg-day	1000	Medium
Hepatic	1 x 10^-3	Increased hepatocellular hypertrophy	NOAEL (HED): 1.27 mg/kg-day	1000	Medium
Developmental	6 x 10^-3	Developmental delays	BMDL (HED): 6.2 x 10^-1 mg/kg-day	100	Low/Medium

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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