Perfluorobutanoic Acid (PFBA)
CASRN 375-22-4 | DTXSID4059916
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (6 pp, 364 K) Last Updated: 12/22/2022
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Endocrine, Hepatic |
1 x 10 -3
(Chronic) |
Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) |
NOAEL
(HED):
1.27
mg/kg-day |
1000 | Medium |
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(6 pp, 364 K)
Last Updated: 12/22/2022
Information reviewed but value not estimated.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (6 pp, 364 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (6 pp, 364 K)
Not assessed under the IRIS Program.
Organ/System-Specific RfDs
| System | RfD (mg/m3) | Basis | PoD | UF | Confidence | Notes |
|---|---|---|---|---|---|---|
| Endocrine, Hepatic |
1
x 10-3
(Chronic) |
Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) |
NOAEL
(HED):
1.27 mg/kg-day |
1000 | Medium | |
| Hepatic |
1
x 10-3
(Chronic) |
Increased hepatocellular hypertrophy |
NOAEL
(HED):
1.27 mg/kg-day |
1000 | Medium | |
| Developmental |
6
x 10-3
(Chronic) |
Developmental delays |
BMDL
(HED):
6.2 x 10-1 mg/kg-day |
100 | Low/Medium | |
| Developmental |
6
x 10-3
(Subchronic) |
Developmental delays |
BMDL
(HED):
6.2 x 10-1 mg/kg-day |
100 | Low/Medium | |
| Hepatic |
1
x 10-2
(Subchronic) |
Increased hepatocellular hypertrophy |
NOAEL
(HED):
1.27 mg/kg-day |
100 | Medium | |
| Endocrine |
1
x 10-2
(Subchronic) |
Decreased total T4 |
NOAEL
(HED):
1.27 mg/kg-day |
100 | Low/Medium | |
| Developmental |
6
x 10-3
(Subchronic) |
Developmental delays |
BMDL
(HED):
6.2 x 10-1 mg/kg-day |
100 | Low/Medium |
Chemical Documents
Other EPA Information
Additional EPA toxicity information may be available by visiting the following sites:
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Related Links
Critical Effects
Chemical Structure
