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Perfluorobutanoic Acid (PFBA)

CASRN 375-22-4 | DTXSID4059916

  • Toxicological Review (PDF) (146 pp, 2.86 M)
  • IRIS Executive Summary (PDF) (6 pp, 364 K)
  • Supplemental Information on the IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts

On this page:

  • Key IRIS
    Values
  • Organ/System
    Specific Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (6 pp, 364 K) Last Updated: 12/22/2022

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Endocrine, Hepatic 1 x 10 -3
(Chronic)
Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) NOAEL (HED): 1.27
mg/kg-day
1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (6 pp, 364 K)

System RfC (mg/m3) Basis PoD Composite UF Confidence

Cancer Assessment

Weight of Evidence for Cancer (PDF) (6 pp, 364 K) Last Updated: 12/22/2022
Information reviewed but value not estimated.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (6 pp, 364 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (6 pp, 364 K)

Not assessed under the IRIS Program.

Organ/System-Specific RfDs

System RfD (mg/m3) Basis PoD UF Confidence Notes
Endocrine, Hepatic 1 x 10-3
(Chronic)
Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) NOAEL (HED): 1.27
mg/kg-day
1000 Medium
Hepatic 1 x 10-3
(Chronic)
Increased hepatocellular hypertrophy NOAEL (HED): 1.27
mg/kg-day
1000 Medium
Developmental 6 x 10-3
(Chronic)
Developmental delays BMDL (HED): 6.2 x 10-1
mg/kg-day
100 Low/Medium
Developmental 6 x 10-3
(Subchronic)
Developmental delays BMDL (HED): 6.2 x 10-1
mg/kg-day
100 Low/Medium
Hepatic 1 x 10-2
(Subchronic)
Increased hepatocellular hypertrophy NOAEL (HED): 1.27
mg/kg-day
100 Medium
Endocrine 1 x 10-2
(Subchronic)
Decreased total T4 NOAEL (HED): 1.27
mg/kg-day
100 Low/Medium
Developmental 6 x 10-3
(Subchronic)
Developmental delays BMDL (HED): 6.2 x 10-1
mg/kg-day
100 Low/Medium

Chemical Documents

Dec 2022: IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Final Report, 2022) (Report)

Nov 2022: IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Interagency Science Discussion Draft Comments, 2022) (Other)

Oct 2021: External Peer Review Activities for PFBA Integrated Risk Information System (IRIS) Assessment (Nov 2021) (Other)

Aug 2021: IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Public Comment and External Review Draft, 2021) (Report)

Aug 2020: Toxicological Review of Perfluorobutanoic Acid and Related Compound Ammonium Perfluorobutanoic Acid (PFBA) (Interagency Science Consultation Draft, 2020) (Report)

Nov 2019: Systematic Review Protocol for the Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid IRIS Assessment (Preliminary Assessment Materials, 2019) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Perfluorobutanoic Acid (PFBA)

Critical Effects

Developmental
Developmental

Endocrine
Endocrine

Hepatic
Hepatic

Chemical Structure

Perfluorobutanoic Acid (PFBA)
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