Perfluorodecanoic Acid (PFDA)
CASRN 335-76-2 | DTXSID3031860
- IRIS Executive Summary (PDF) (7 pp, 403 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(7 pp, 403 K)
Last Updated: 07/15/2024
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Immune | 2 x 10 -9
(Chronic) |
Decreased serum antibody concentrations for tetanus and diphtheria in children at age 7 yr and PFDA measured at age 5 yr. |
BMDL
(HED):
6.04
x 10-8 mg/kg-day |
30 | Medium |
| Immune | 2 x 10 -9
(Subchronic) |
Decreased serum antibody concentrations for both tetanus and diphtheria in children at age 7 yr and PFDA measured at age 5 yr |
BMDL
(HED):
6.04
x 10-8 mg/kg-day |
30 | Medium |
Note: BMDL of 1/2 SD
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(7 pp, 403 K)
Last Updated: 07/15/2024
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(7 pp, 403 K)
Last Updated: 07/15/2024
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (7 pp, 403 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (7 pp, 403 K)
Not assessed under the IRIS Program.
Organ/System-Specific RfDs
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence | Notes |
|---|---|---|---|---|---|---|
| Immune |
2
x 10-9
(Chronic) |
Decreased serum antibody concentrations for tetanus and diphtheria in children at age 7 yr and PFDA measured at age 5 yr. |
BMDL
(HED):
6.04 x 10-8 mg/kg-day |
30 | Medium | BMDL 1/2 SD |
| Developmental |
2
x 10-9
(Chronic) |
Decreased birth weight in male and female children. |
BMDL
(HED):
5.44 x 10-8 mg/kg-day |
30 | Medium-Low | BMDL 5% RD |
| Immune |
2
x 10-9
(Subchronic) |
Decreased serum antibody concentrations for both tetanus and diphtheria in children at age 7 yr and PFDA measured at age 5 yr |
BMDL
(HED):
6.04 x 10-8 mg/kg-day |
30 | Medium | BMDL 1/2 SD |
| Developmental |
2
x 10-9
(Subchronic) |
Decreased birth weight in male and female children. |
BMDL
(HED):
5.44 x 10-8 mg/kg-day |
30 | Medium-Low | BMDL 5% RD |
| Hepatic |
6
x 10-7
(Subchronic) |
Increased relative Liver weight in SD female rats |
BMDL
(HED):
5.92 x 10-4 mg/kg-day |
1000 | Medium | BMDL 10% RD |
| Reproductive |
3
x 10-6
(Subchronic) |
Decreased absolute whole epididymis weight in SD rats (Male Reproductive). |
BMDL
(HED):
2.77 x 10-3 mg/kg-day |
1000 | Medium-Low | BMDL 1 SD |
| Reproductive |
1
x 10-6
(Subchronic) |
Increased number of days spent in diestrus in SD rats (Female Reproductive). |
BMDL
(HED):
1.12 x 10-3 mg/kg-day |
1000 | Medium-Low | BMDL 5% RD |
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Critical Effect Systems
Chemical Structure for
Perfluorodecanoic Acid (PFDA)
