Perfluorohexanesulfonic Acid (PFHxS)
CASRN 355-46-4 | DTXSID7040150
- Toxicological Review (PDF) (493 pp, 24.04 M)
- IRIS Summary (PDF) (6 pp, 413 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(6 pp, 413 K)
Last Updated:
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Developmental, Immune | 4 x 10 -10
(Chronic) |
Decreased serum anti-tetanus antibody concentration in children at age 7 yrs (Grandjean et al., 2012; Budtz-Jorgensen and Grandjean, 2018) |
BMDL
(HED):
1.16
x 10-8 mg/kg-day |
30
MF: None |
Medium |
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(6 pp, 413 K)
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Not available. |
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (6 pp, 413 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (6 pp, 413 K)
Not assessed under the IRIS Program.
Organ/System-Specific RfDs
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence | Notes |
|---|---|---|---|---|---|---|
| Developmental, Immune |
4
x 10-10
(Chronic) |
Decreased serum anti-tetanus antibody concentration in children at age 7 yrs (Grandjean et al., 2012; Budtz-Jorgensen and Grandjean, 2018) |
BMDL
(HED):
1.16 x 10-8 mg/kg-day |
30 | Medium | |
| Endocrine |
2
x 10-7
(Chronic) |
Decreasedserum total T4 levels in F1 Wistar rats (Ramhoj et al., 2018) |
NOAEL
(HED):
2.45 x 10-5 mg/kg-day |
100 | Medium | |
| Developmental, Immune |
4
x 10-10
(Subchronic) |
Decreased serum anti-tetanus antibody concentration in children at age 7 yrs (Grandjean et al., 2012; Budtz-Jorgensen and Grandjean, 2018) |
BMDL
(HED):
1.16 x 10-8 mg/kg-day |
30 | Medium | |
| Endocrine |
2
x 10-7
(Subchronic) |
Decreased serum total T4 levels in F1 Wistar rats (Ramhoj et al., 2018) |
NOAEL
(HED):
2.45 x 10-5 mg/kg-day |
100 | Medium |
Additional EPA toxicity information may be available by visiting the following sites:
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
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Critical Effect Systems
Chemical Structure for
Perfluorohexanesulfonic Acid (PFHxS)
