Pentachlorophenol
CASRN 87-86-5 | DTXSID7021106
- Toxicological Review (PDF) (288 pp, 2.23 M)
- IRIS Summary (PDF) (27 pp, 261 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (27 pp, 261 K) Last Updated: 09/30/2010
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 5 x 10 -3 | Hepatotoxicity |
LOAEL
:
1.5
mg/kg-day |
300 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (27 pp, 261 K) Last Updated: 09/30/2010
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(27 pp, 261 K)
Last Updated: 09/30/2010
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Likely to be carcinogenic to humans | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), PCP is "likely to be carcinogenic to humans."
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 261 K)
Oral Slope Factor:
4
x 10-1
per mg/kg-day
Drinking Water Unit Risk:
1.1
x 10-5
per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the POD (LED10).
Tumor site(s): Hepatic, Endocrine
Tumor type(s): Hepatocellular adenomas or carcinomas and adrenal benign or malignant pheochromocytomas (NTP, 1989)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 261 K)
Not Assessed under the IRIS Program.
Chemical Documents
Sep 2010: IRIS Toxicological Review of Pentachlorophenol (Final Report) (Report)
Jul 2010: IRIS Toxicological Review of Pentachlorophenol (Interagency Science Discussion Draft) (Report)
May 2009: IRIS Toxicological Review of Pentachlorophenol (External Review Draft) (Report)
May 2002: PENTACHLOROPHENOL: HEALTH AND ENVIRONMENTAL EFFECTS PROFILE (Report)
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Critical Effects
Chemical Structure
Synonyms
- Chem-Tol
- Chlorophen
- Cryptogil OL
- DP-2, technical
- Dowcide 7
- Dowicide EC-7
- Durotox
- EP 30
- Fungifen
- Glazd penta
- Grundier arbezol
- Lauxtol
- Lauxtol A
- Liroprem
- NCI-C54933
- NCI-C55378
- NCI-C55389
- NCI-C56655
- PCP
- Penchlorol
- Penta
- Penta-Kil
- Pentachloorfenol
- Pentachlorofenol
- Pentachlorofenolo
- Pentachlorophenate
- Pentachlorophenol
- Pentachlorphenol
- Pentaclorofenolo
- Pentacon
- Pentasol
- Penwar
- Peratox
- Permacide
- Permagard
- Permasan
- Permatox
- Permatox dp-2
- Permatox penta
- Permite
- Phenol, pentachloro-
- Preventol P
- Priltox
- Santobrite
- Santophen
- Santophen 20
- Sinituho
- Term-i-trol
- WLN: QR BG CG DG EG FG
- 1-Hydroxy- 2,3,4,5,6-pentachlorobenzene
- 2,3,4,5,6-Pentachlorophenol
- 87-86-5