Phenol
CASRN 108-95-2 | DTXSID5021124
- Toxicological Review (PDF) (213 pp, 2.96 M)
- IRIS Summary (PDF) (31 pp, 194 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(31 pp, 194 K)
Last Updated: 09/30/2002
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Other | 3 x 10 -1 | Decreased maternal weight gain |
BMDL
:
93
mg/kg-day |
300 | Medium/High |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(31 pp, 194 K)
Last Updated: 09/30/2002
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(31 pp, 194 K)
Last Updated: 09/30/2002
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
| Data are inadequate for an assessment of human carcinogenic potential | Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999) |
- Under Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), the data regarding the carcinogenicity of phenol via the oral, inhalation, and dermal exposure routes are inadequate for an assessment of human carcinogenic potential. Phenol was negative in oral carcinogenicity studies in rats and mice, but questions remain regarding increased leukemia in male rats in the bioassay as well as the positive gene mutation data and the positive results in dermal initiation/promotion studies at doses at or above the maximum tolerated dose (MTD). No inhalation studies of an appropriate duration exist. Therefore, no quantitative assessment of carcinogenic potential via any route is possible.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (31 pp, 194 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (31 pp, 194 K)
Not assessed under the IRIS Program.
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Chemical Structure for
Phenol
