Phosphine CASRN 7803-51-2 | IRIS

IRIS

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Other	3 x 10 ^-4	Body weight and clinical parameters	NOEL : 2.6 x 10^-2 mg/kg-day	100	Medium

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Other	3 x 10 ^-4	Decreased body weight	NOAEL (HEC): 2.5 x 10^-1 mg/m³	1000	Low

Weight of Evidence for Cancer (PDF) (146 pp, 20 K) Last Updated: 09/01/1992

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Based on inadequate data in animals and no tumor data in humans. While phospine has not been associated with cancer in humans, there is some evidence of chromosomal damage (transient chromatid deletions, gaps and breaks, persistent chromosomal translocations). A relationship between these genetic effects and the development of cancer in humans is sometimes postulated.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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