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Silver

CASRN 7440-22-4 | DTXSID4024305

  • IRIS Summary (PDF) (14 pp, 120 K)

On this page:

  • Key IRIS
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 120 K) Last Updated: 12/01/1991

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Dermal 5 x 10 -3 Argyria LOAEL : 1.4 x 10-2
mg/kg-day
3 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 120 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (14 pp, 120 K) Last Updated: 06/01/1989

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • In animals, local sarcomas have been induced after implantation of foils and discs of silver. However, the interpretation of these findings has been questioned due to the phenomenon of solid-state carcinogenesis in which even insoluble solids such as plastic have been shown to result in local fibrosarcomas.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 120 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 120 K)

Not assessed under the IRIS Program.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Silver
  • eChemPortal - Silver

Critical Effects

Dermal
Dermal

Chemical Structure

Silver

Synonyms

  • Argentum crede
  • Collargol
  • Silver
  • 7440-22-4
  • IRIS Home
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