Concepts, Methods, and Data Sources For Cumulative Health Risk Assessment of Multiple Chemicals, Exposures and Effects: A Resource Document (Final Report, 2008)
Overview
- initiating factors for a cumulative risk assessment, with procedures for data collection and organization, and
- technical approaches for assessing human health risks associated with a multiple chemicals, exposures and effects.
Citation
Background
- Procedures for population characterization, data collection and data organization based on the initiating factors for a cumulative risk assessment
- A chemical grouping method to scope analyses into manageable pieces to be assessed as multiple chemicals with co-occurring exposures and common toxicity
- Approaches and data sources for evaluating the timing of exposures, including discussions of chemical degradation over time in the environment and of kinetics and dynamics
- Integration of internal dose measurements to account for multiple route exposures
- Estimation of mixture risks for multiple route exposures by calculating route-specific risks using the Relative Potency Factor (RPF) approach and then summing the route-specific RPF-based risks across routes
- Integration of output from multiple effects modeling (illustrated using a categorical regression model) with the Hazard Index (HI) and response addition models to express risks for multiple health effects
- Detail on the cumulative HI approach, including impacts for risk characterization
- Refinement of the interaction-based HI method to account for toxicological interactions
- A method for cumulative risk characterization that considers factors unique to the conduct of a cumulative risk assessment, including uncertainties in cumulative dose-response and exposure assessment
- A general emphasis on integrating exposure and dose-response analysis
- A Risk Assessment Toolbox (Appendix A) that provides numerous sources of data and tools for use in conducting a cumulative risk assessment.
History/Chronology
Date | Description |
---|---|
Feb 2001 | NCEA began work developing cumulative risk approaches and information through an Interagency Agreement with the Department of Energy (DOE). |
May 2003 | EPA's Risk Assessment Forum (RAF) released the 2003 Framework for Cumulative Risk Assessment. |
Mar 2006 | EPA released the Considerations for Developing Alternative Health Risk Assessment Approaches for Addressing Multiple Chemicals, Exposures and Effect (External Review Draft) for public review and comment. |
May 2006 | EPA hosted an external peer review workshop for Considerations for Developing Alternative Health Risk Assessment Approaches for Addressing Multiple Chemicals, Exposures and Effect. |
Jun 2008 | EPA released the final report. |
Download(s)
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
- U.S. EPA. Concepts, Methods and Data Sources for Cumulative Health Risk Assessment of Multiple Chemicals, Exposures and Effects: A Resource Document. ORD, NCEA, Cincinnati, OH. EPA/600/R-06/013F, 2007 (PDF) (412 pp, 14.9 MB, about PDF)
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Document Related Link(s)
- EPA Science Policy Council Risk Assessment Program - Current Projects
- U.S. EPA. Framework for Cumulative Risk Assessment
- U.S. EPA. Guidance on Cumulative Risk Assessment. Part 1 Planning and Scoping
- Guidance on Cumulative Risk Assessment of Pesticide Chemicals That Have a Common Mechanism of Toxicity
- Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures