Chromium(VI)
CASRN 18540-29-9 | DTXSID7023982
- Toxicological Review (PDF) (538 pp, 9.6 MB)
- IRIS Summary (PDF) (14 pp, 461.9 KB)
IRIS Toxicological Review of Hexavalent Chromium (2010 Interagency Science Consultation Draft)
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Overview
Citation
Background
Chromium is a naturally occuring element in the earth's crust. The three main forms of chromium found in the environment are chromium (0), chromium (III), and chromium (VI), also known as hexavalent chromium. Chromium is widely used in manufacturing processes, and it can be found in many consumer products such as wood treated with copper dichromate, leather tanned with chromic sulfate, and stainless steel cookware. Chromium is released to the environment from natural and anthropogenic sources, with the largest releases occurring from industrial sources. The general population may be exposed to chromium by inhaling ambient air, ingesting food, and drinking water containing chromium. Dermal exposure of the general public to chromium can occur from skin contact with certain consumer products or soils that contain chromium.
History/Chronology
| Date | Description |
|---|---|
| Sep 1998 | The oral RfD for hexavalent chromium was posted to the IRIS database. The inhalation RfC for hexavalent chromium and the carcinogenicity assessment for hexavalent chromium were also posted to the IRIS database. |
| May 2010 | EPA initiated the interagency science consultation on the draft Toxicological Review of Hexavalent Chromium. |
| Sep 2010 | EPA released the external review draft for public review and comment. Additionally, EPA released the draft toxicological review and federal agency comments from the Interagency Science consultation. |
Status
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Hexavalent Chromium (Interagency Science Consultation Draft) (PDF) (260 pp, 1.8 MB, about PDF)
- Charge to External Reviewers (Interagency Science Consultation Draft) (PDF) (2 pp, 20.5 KB, about PDF)
- ATSDR Comments of the Review of Hexavalent Chromium (PDF) (2 pp, 22.5 KB, about PDF)
- DOD Comments of the Review of Hexavalent Chromium (PDF) (15 pp, 133.8 KB, about PDF)
- DOD Comments of the charge questions for the Review of Hexavalent Chromium (PDF) (2 pp, 21.5 KB, about PDF)
- NTP Comments of the Review of Hexavalent Chromium (PDF) (2 pp, 397.5 KB, about PDF)
- OMB Comments of the Review of Hexavalent Chromium (PDF) (4 pp, 32.2 KB, about PDF)
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Critical Effect Systems
Tumor Sites
Chemical Structure for
Chromium(VI)
