n-Butanol

Overview

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of n-butanol that will appear in the Integrated Risk Information System (IRIS) database.

Background

The draft Toxicological Review of n-Butanol provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to n-butanol. n-Butanol is widely used as an organic solvent and is an intermediate in the manufacture of other organic chemicals such as acetates, acrylates and glycol ethers. n-Butanol is also a natural component of many foods and formed during the fermentation of carbohydrates.

History/Chronology

Date	Description
Mar 1987	A RfD was posted for n-butanol to the IRIS Database.
Mar 1991	The cancer assessment for n-butanol was posted to the IRIS Database.
Jun 2011	EPA initiated the interagency science consultation on the draft Toxicological Review of n-Butanol.
Sep 2011	EPA released the external review draft for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.

Status

Following external peer review and public comment, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA and other federal agencies and White House offices. After completing the review it will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2011-0671" (for the docket ID) to comment on this report.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• IRIS Toxicological Review of n-Butanol (External Review Draft) (PDF)  (136  pp, 882.8 KB, about PDF)
• Charge to External Peer Reviewers (PDF)  (3  pp, 28.3 KB, about PDF)

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Document Related Link(s)

• IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft)

Federal Register Notices

• FR Notice: Nov 16, 2011
• FR Notice: Sep 15, 2011
• FR Notice: Aug 31, 2011