1,2,3-Trichloropropane

Overview

On September 30, 2009, the IRIS Summary and Toxicological Review of 1,2,3-trichloropropane (TCP) was finalized and loaded onto the IRIS database. The Toxicological Review of TCP was reviewed internally by EPA, by other federal agencies and White House Offices, by expert external peer reviewers, and by the public. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency draft of the TCP IRIS assessment are posted on this site.

Background

The draft Toxicological Review of 1,2,3-Trichloropropane provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to 1,2,3-trichloropropane. 1,2,3-Trichloropropane is an important industrial chemical used as a solvent for oils and fats, waxes, and resins, and has also been used in paint thinner and varnish remover and as a degreasing agent. 1,2,3-Trichloropropane is also generated as a by-product of the production of other chlorinated compounds such as epichlorohydrin, and is used as an intermediate in the production of some pesticides and polymers, such as polysulfide rubbers.

This assessment contains the derivation of a chronic reference dose and a chronic reference concentration, as well as a cancer characterization and the derivation of an oral slope factor.

History/Chronology

Date	Description
2003	EPA began developing the Toxicological Review of 1,2,3-trichloropropane.
Nov 2007	EPA released an External Review Draft for public comment and review.
Jan 2008	EPA announced the external peer review panel meeting in a Jan 18, 2008 Federal Register Notice.
Sep 2009	EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of 1,2,3-trichloropropane. These comments are provided on this web site.
Sep 2009	EPA released the Final Toxicological Review (PDF) (247 pp, 1.9M) and accompanying Summary for 1,2,3-Trichloropropane to the IRIS Web site.

Status

The assessment has been finalized and loaded onto the IRIS database.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Draft) (PDF)  (254  pp, 1.1 MB, about PDF)
• IRIS Summary for 1,2,3-Trichloropropane (Interagency Science Discussion Draft) (PDF)  (26  pp, 125.0 KB, about PDF)
• OMB Comments for the IRIS Summary and Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Drafts) (PDF)  (4  pp, 33.2 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

• IRIS Toxicological Review of 1,2,3-Trichloropropane (External Review Draft)