IRIS

Urea

CASRN 57-13-6 | DTXSID4021426

IRIS Toxicological Review of Urea (Interagency Science Consultation Draft)

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Overview

On September 28, 2010, the Toxicological Review of Urea and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the IRIS Toxicological Review of Urea and the charge to external peer reviewers are posted on this site.

Citation

U.S. EPA. IRIS Toxicological Review of Urea (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/005C, 2010.

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Background

The draft Toxicological Review of Urea provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to Urea. Urea, also known as carbamide, is an endogenous product of protein and amino acid catabolism. It can also be produced synthetically by combining ammonia, carbon monoxide, and sulfur in methanol. Urea is utilized in diesel selective catalyst reduction, in fertilizers and animal feed, plastics, flame-proofing agents, adhesives, flavoring agents and consumer goods such as liquid soaps, detergents and household cleaning products.

History/Chronology

Date Description
02- Jun 2010 EPA initiated the interagency science consultation on the draft Toxicological Review of Urea.
03- Sep 2010 EPA released the External Review Draft for public review and comment. EPA also announced a public listening session to be held on Nov 16, 2010. [Federal Register September 28, 2010]

Status

Following external peer review the assessment will be revised taking into consideration external peer review and public comments. It will then undergo a final EPA internal review and a review by other federal agencies and White House offices, followed by posting to the IRIS Web site.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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Document Related Link(s)

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Related Links

Chemical Structure for
Urea

Urea

Synonyms

  • Aquacare
  • Aquadrate
  • Basodexan
  • Carbamide
  • Carbonyldiamide

    • more synonyms