IRIS Toxicological Review of Inorganic Arsenic (Cancer) (External Review Draft, 2010)

IRIS

Arsenic, Inorganic

CASRN 7440-38-2 | DTXSID4023886

IRIS Summary (PDF) (29 pp, 181.6 KB)
Workshop & meeting details from the development of the draft IRIS Assessment for inorganic arsenic
Status: arsenic, inorganic is in step 4 at this time.

On this page:

Overview
Background
Downloads

Notice - This site contains archived material(s)

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Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the Risk Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

EPA's Science Advisory Board (SAB) conducted a review of the scientific basis supporting the human health cancer hazard and dose-response assessment of inorganic arsenic that will appear on the Integrated Risk Information System (IRIS) database. EPA revised the assessment and is now returning the assessment to the SAB and releasing the document to the public for a focused review of EPA's responses to the SAB recommendations.

Citation

U.S. EPA. IRIS Toxicological Review of Inorganic Arsenic (Cancer) (External Review Draft, 2010). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/001, 2010.

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Background

Inorganic arsenic is used for hardening copper and lead alloys. It also is used in glass manufacturing as a decolorizing and refining agent, as a component of electrical devices, in the semiconductor industry, and as a catalyst in the production of ethylene oxide. Arsenic compounds are used as a mordant in the textile industry, for preserving hides, as medicinals, pesticides, pigments, and wood preservatives. Approximately 90% of the domestic consumption of arsenic is currently used with production of chromated copper arsenate (CCA), a wood preservative, the production of which is currently being phased out. Arsenic is also found naturally in the environment and is typically present in soil and water at detectable levels. Sources of human exposure to inorganic arsenic include drinking water, diet, air, and soils (which can contain naturally occurring arsenic or contamination from anthropogenic sources). This draft IRIS health assessment addresses only cancer human health effects that may result from chronic exposure to this chemical. An assessment of noncancer health effects of inorganic arsenic will be released for external peer review and public comment at a later date.

History/Chronology

Date	Description
01- 1988	EPA published the IRIS Health Hazard Assessment for Inorganic Arsenic.
02- 1999	NRC reviewed the 1988 IRIS assessment and the available health data for inorganic arsenic and made recommendations for updating the cancer assessment in Arsenic in Drinking Water.
03- 2001	NRC updated the NRC (1999) report and evaluated the toxicological risk and health effects of arsenic as relevant to the 2001 Arsenic Rule in Arsenic in Drinking Water – 2001 Update.
04- 2001	NRC reviewed the 2001 Primary Drinking Water Standard for inorganic Arsenic and made recommendations for applying epidemiologic data in the cancer health assessment.
05- 2003	EPA started a reassessment of the IRIS assessment for inorganic arsenic.
06- Jul 2005	EPA submitted the reassessment of cancer assessment for inorganic arsenic to EPA's Science Advisory Board (SAB) for review.
07- Jun 2007	SAB posted a response to the 2005 EPA reassessment of inorganic arsenic (cancer). [See related links (below) or Link to the SAB Report and Review Panel Meetings]
08- Oct 2008	The draft IRIS Toxicological Review for Inorganic Arsenic (cancer) was submitted to OMB for interagency review.
09- Jun 2009	EPA hosted an interagency science consultation on the draft IRIS Toxicological Review of Inorganic Arsenic.
10- Feb 2010	EPA released the draft IRIS Toxicological Review for Inorganic Arsenic (cancer) to SAB and simultaneously to the public for review and comment, focusing on EPA's responses to the SAB (2007) report.
11- Oct 2010	SAB announced a public teleconference to conduct a quality review of the draft report to be held on November 22, 2010. [Federal Register Oct 25, 2010]

Status

This draft has been archived. The re-assessment will start again at step 1.

Supporting Documents: The file, Arsenic_Excel_Table 5-3.zip (ZIP, 195 Kb), provides the data and analyses EPA used to derive the cancer risk estimates as described in Table 5-3 in the Toxicological Review of Inorganic Arsenic (Cancer) (External Review Draft) 2010. An additional file (Arsenic_Excel_Appendix F.zip (ZIP, 143 Kb), ) provides the data and analyses EPA used to derive the results presented in Appendix F (Tables F-1 and F-2). Information regarding the files can be found on the first tab (labeled Directions) of each individual Excel® file.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

IRIS Toxicological Review of Inorganic Arsenic (Cancer) (External Review Draft) (PDF) (575 pp, 6.5 MB, about PDF)
Arsenic_ Excel_ Table 5-3.zip (ZIP, 195 Kb) (ZIP) (190.4 KB, about ZIP)
Arsenic_ Excel_ Appendix F.zip (ZIP, 143 Kb) (ZIP) (138.7 KB, about ZIP)
Charge to External Peer Reviewers (SAB) (PDF) (3 pp, 25.4 KB, about PDF)
SAB Advisory on EPA’s Assessments of Carcinogenic Effects of Organic and Inorganic Arsenic: A Report of the US EPA Science Advisory Board (July 2007) (PDF) (88 pp, 422.9 KB, about PDF)
IA Response to Comments (PDF) (1 pp, 112.3 KB, about PDF)

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Document Related Link(s)

Federal Register Notices

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US EPA

IRIS

Arsenic, Inorganic

CASRN 7440-38-2 | DTXSID4023886