Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised July 2013 External Review Draft) (Public Comment Draft)

IRIS

Ethylene oxide

CASRN 75-21-8 | DTXSID0020600

Toxicological Review (PDF) (228 pp, 1.8 MB)
IRIS Executive Summary (PDF) (9 pp, 202.1 KB)
Background, History, and Other Supporting Documents (including Appendices)

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Overview
Background
Downloads

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Overview

EPA is initiating a public comment period prior to peer review of the scientific basis supporting the human health hazard and dose-response assessment of ethylene oxide (cancer) that will appear in the Integrated Risk Information System (IRIS) database.

Citation

U.S. EPA. Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised July 2013 External Review Draft) (Public Comment Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-13/128A, 2013.

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Background

Ethylene Oxide (EtO) is a gas at room temperature used in chemical manufacturing and as a sterilizing agent for medical equipment and a fumigating agent for spices. Human exposure occurs in occupations involving contact with the gas in production facilities and hospitals that sterilize medical equipment. EtO can also be inhaled by residents living near production or sterilizing/fumigating facilities.

History/Chronology

Date	Description
17- Aug 2013	EPA announced a request for nominations for experts to augment the SAB CAAC to form a panel for the review of the EPA's draft IRIS Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised External Review Draft). [Federal Register Notice Aug 28, 2013]
16- Aug 2013	EPA announced an extension of the public comment period from September 5 to October 11, 2013. [Federal Register Notice Aug 28, 2013]
15- Jul 2013	EPA revised the draft assessment and released for additional public review and comment (step 4 of the IRIS process). The interagency science discussion draft of the assessment and related comments are also available. [Federal Register Notice Jul 23, 2013]
13- Jun 2012	EPA conducted further Agency review of a revised draft.
12- Jul 2011	EPA initiated Final Agency and Interagency Science Discussion (step 6 of the IRIS process) of the draft assessment of EtO.
11- Dec 2007	EPA's SAB issued a final report on the review of the draft assessment of EtO.
10- Jan 2007	Peer review meeting of the Science Advisory Board (SAB) (public meeting).
07- Oct 2006	A 30-day extension is given for the public comment period. [Federal Register Notice October 12, 2006]
06- Sep 2006	EPA released the draft assessment for a 30-day public comment period. [Federal Register Notice September 22, 2006]
05- Aug 2006	Completion of external Federal agencies review of EPA's draft assessment of carcinogenicity of EtO.
04- Mar 2006	Completion of internal EPA review of draft assessment of carcinogenicity of EtO.
03- Dec 1998	EPA begins work on new assessment of carcinogenicity of EtO.
02- Jun 1985	EPA published the Health Assessment Document for Ethylene Oxide (Final) (EPA-600/8-84/009F).
01- Apr 1984	EPA released the Health Assessment Document for Ethylene Oxide (External Review Draft)(EPA-600/8-84/009A).

Status

EPA’s SAB will be taking nominations and forming a peer review panel, and announcing the final panel and a public comment period for the revised external review draft IRIS Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide. Information on the peer review can be found at the SAB web site at http://yosemite.epa.gov/sab/sabproduct.nsf/fedrgstr_activites/Eto%20Inhalation%20Carcinogenicity?OpenDocument. The SAB will announce the dates and details for their peer review meeting on their web site. Following external peer review, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA, and other federal agencies and the Executive Office of the President. After completing this review it will be posted to the IRIS database.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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Document Related Link(s)

Federal Register Notices

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2006-0756

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US EPA

IRIS

Ethylene oxide

CASRN 75-21-8 | DTXSID0020600