1,2,4-Trimethylbenzene
CASRN 95-63-6 | DTXSID6021402
- Toxicological Review (PDF) (150 pp, 2.5 MB)
- IRIS Executive Summary (PDF) (10 pp, 315.4 KB)
- Supplemental Information on the IRIS Toxicological Review of Trimethylbenzene
IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Discussion Draft)
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Overview
Citation
Background
Effects on the nervous, respiratory, and hematological (i.e., blood) systems have been reported in occupationally- and residentially-exposed humans, but these effects were observed following exposure to complex mixtures containing TMB isomers, thus making it difficult to determine the contribution of each TMB isomer to the observed health effects. Health effects that are roughly analogous to those seen in humans have been observed in animals exposed to the individual isomers. Effects on the nervous system, including cognitive effects and decreased pain sensitivity, are the most widely observed effects in animals. Effects on other systems, including the respiratory and hematological systems, have also been observed in animals. Both 1,2,4-TMB and 1,3,5-TMB have been observed to elicit effects on pregnant animals and developing fetuses, but at exposure levels greater than those that cause effects on the nervous system. There is inadequate information to evaluate the carcinogenicity of TMBs.
History/Chronology
Status
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Trimethylbenzes (Interagency Science Discussion Draft) (PDF) (148 pp, 2.4 MB, about PDF)
- IRIS Toxicological Review of Trimethylbenzes (Interagency Science Discussion Draft) -- Supplemental Information (PDF) (353 pp, 9.6 MB, about PDF)
- EPA's Response to select Interagency Science Discussion Comments (PDF) (2 pp, 120.1 KB, about PDF)
- 1. DoD Comments on Trimethylbenzenes (PDF) (8 pp, 63.5 KB, about PDF)
- 2. OMB Email Comments on Trimethylbenzenes (PDF) (1 pp, 191.4 KB, about PDF)
- 3. OMB Comments on Trimethylbenzenes (PDF) (1 pp, 163.1 KB, about PDF)
- 4. SBA Comments on Trimethylbenzenes (PDF) (4 pp, 692.4 KB, about PDF)
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