tert-Butyl Alcohol (tBA)

CASRN 75-65-0 | DTXSID8020204

Toxicological Review (PDF) (156 pp, 2.3 MB, about PDF)
IRIS Executive Summary (PDF) (7 pp, 302.7 KB, about PDF)
Supplemental Information on the IRIS Toxicological Review of Tert-Butyl Alcohol

IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (External Review Draft, 2017)

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Overview
Background
Downloads

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Overview

The IRIS Toxicological Review of tert-Butyl Alcohol (tert-Butanol or tBA) was released for external peer review in June 2017. EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis supporting the tBA assessment and release a final report of their review. Information regarding the peer review can be found on the SAB website.

Background

tert-Butyl Alcohol (tBA) is used as a solvent; as a denaturant for ethanol and several other alcohols; in the manufacture of flotation agents, fruit essences, and perfumes; as an octane booster in gasoline; as a dehydrating agent; and as a chemical intermediate in the manufacture of methyl methacrylate. tBA's production for industrial uses may result in its direct release to the environment through various waste streams. tBA is also a likely degradation product of methyl tert-butyl ether (MTBE). Probable routes of human exposure to tBA include inhalation, ingestion, and skin or eye contact.

History/Chronology
Date	Description
Aug 2013	EPA released preliminary assessment materials (draft literature searches and associated search strategies, evidence tables and exposure response arrays) for discussion at an IRIS Public Science Meeting.
Dec 2013	EPA discussed tert-butanol at the December 2013 IRIS public science meeting.
Sep 2014	EPA sent an interagency science consultation draft for review and comment.
May 2016	EPA released the public comment draft for public review and comment.
Jun 2016	EPA convened a public science meeting June 29-30, 2016 to discuss the public comment draft.
Jun 2017	EPA released the external review draft and charge to reviewers prior to the public peer review meeting.[SAB FR Notice Jun 16, 2017]
Jul 2017	EPA's Science Advisory Board (SAB) hosted a public teleconference to discuss the draft assessment.
Aug 2017	EPA's SAB hosted a 2-day public meeting on August 15-17, 2017, to discuss the draft assessment.
Feb 2019	EPA's SAB released a final report of their review of the draft IRIS assessment (see downloads).

Status

Following external peer review, the assessment will be revised. The assessment will then undergo a final EPA internal review and a review by other federal agencies and the Executive Office of the President. Once final, the assessment will be posted to the IRIS database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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