Chloroform
CASRN 67-66-3 | DTXSID1020306
- Toxicological Review (PDF) (112 pp, 741.2 KB)
- IRIS Summary (PDF) (41 pp, 228.5 KB)
- Status: chloroform is in step 4 at this time.
Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials)
Notice
Overview
Citation
Background
Therefore, humans may be exposed to chloroform not only by ingestion of chloroform in drinking water, food, or soil, but also by dermal contact with contaminated media (especially water) and by inhalation of vapor (especially in indoor air).
History/Chronology
| Date | Description |
|---|---|
| Sep 1984 | EPA released the Health Effects Assessment for Chloroform. |
| Apr 1988 | EPA released the Updated Health Effects Assessment for Chloroform. |
| Oct 2001 | EPA released the final toxicological report and summary document and posted these to the IRIS database. |
| Sep 2017 | EPA released the IRIS Assessment Plan (IAP) for Chloroform for public comment and review. [Federal Register Notice Sep 18, 2017] |
| Sep 2017 | EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) discussed the draft document at a public meeting on September 27-28, 2017. |
| Jan 2018 | EPA released the Systematic Review Protocol for the IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials). [Federal Register Notice Jan 31, 2018] |
| Dec 2024 | EPA released an update to the IRIS Chloroform (inhalation) protocol. |
Status
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Systematic Review Protocol for the IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials) (PDF) (76 pp, 1.2 MB, about PDF)
- SAB Briefings on IRIS Assessment Plan for Chloroform
- An Update to the Systematic Review Protocol for the IRIS Toxicological Review of Chloroform (Inhalation) (Dec 2024) (PDF) (151 pp, 2.0 MB, about PDF)
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