IRIS

Ammonia

CASRN 7664-41-7 | DTXSID0023872

IRIS Assessment Plan for Ammonia and Ammonium Salts Noncancer Oral (Scoping and Problem Formulation Materials, Suspended)

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Notice

[UPDATE] EPA suspended the Ammonia and Ammonium Salts (noncancer oral exposure) assessment in fiscal year 2019. This assessment may be restarted as Agency priorities change. For more information, visit the IRIS Program Outlook (Apr 2019).

Overview

In April 2018, EPA released the draft IRIS Assessment Plan for Ammonia and Ammonium Salts Noncancer Oral. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures.

Citation

U.S. EPA. IRIS Assessment Plan for Ammonia and Ammonium Salts Noncancer Oral (Scoping and Problem Formulation Materials, Suspended). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-18/041, 2018.

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Background

Ammonia occurs naturally in air, soil, and water. Ammonia is also produced by humans and other animals as part of normal biological processes. Ammonia is used as an agricultural fertilizer and in many cleaning products. Exposure to ammonia occurs primarily through breathing air containing ammonia gas, and may also occur via diet, drinking water, or direct skin contact.

History/Chronology

Date Description
01- Apr 2019 EPA suspended the Ammonia and Ammonium Salts (noncancer oral exposure) assessment in fiscal year 2019. This assessment may be restarted as Agency priorities change.
02- Apr 2018 EPA released the IRIS Assessment Plan for Ammonia and Ammonium Salts (noncancer oral exposure) for a 30-day public comment period.[Federal Register Notice Apr 16, 2018]
03- Sep 2016 EPA released the final IRIS Toxicological Review of Ammonia (noncancer Inhalation) to the IRIS database.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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Document Related Link(s)


HERO Project


Federal Register Notices

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Related Links

Critical Effect Systems

Respiratory
Respiratory

Chemical Structure for
Ammonia

Ammonia

Synonyms

  • Am-Fol
  • Ammonia
  • Ammonia
  • Ammonia gas
  • Ammonia solution, strong

    • more synonyms