IRIS

Methylmercury (MeHg)

CASRN 22967-92-6 | DTXSID9024198

IRIS Assessment Plan for Methylmercury (Scoping and Problem Formulation Materials)

On this page:

Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the Risk Webmaster for assistance. Please use the contact us form if you need additional support.


Overview

In April 2019, EPA released the draft IRIS Assessment Plan (IAP) for Methylmercury for public review and comment. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure measures and outcome measures. The IAP serves to inform the subsequent development of the chemical specific systematic review protocol.

Citation

U.S. EPA. IRIS Assessment Plan for Methylmercury (Scoping and Problem Formulation Materials). U.S. EPA Office of Research and Development, Washington, DC, EPA/635/R-18/292, 2019.

Top of Page


Background

Gaseous elemental mercury is released into the atmosphere from natural (e.g., volcanoes) and manmade (e.g., fossil-fuel combustion) sources. Elemental mercury can be converted to inorganic mercury, which then can be transported and deposited to land or water. Methylmercury is formed from methylation of inorganic mercury by biota in water and soil. Once converted, methylmercury bioaccumulates in fish tissue and increases in concentration at successively higher levels of the food chain.

The general population is predominantly exposed to methylmercury through consumption of contaminated fish and other seafood. Subsistence fishing communities and other populations with high dietary intakes of predatory fish species could be exposed to higher-than-average levels of methylmercury. Contaminated rice and rice-based food products, such as infant cereals, also can be a source of methylmercury exposure.

Methylmercury readily crosses the placenta and concentrates in cord blood. It is also transferred from mothers to children via breastmilk. The developing nervous system is particularly sensitive to methylmercury, so gestational, lactational, and other postnatal exposures are of concern.

History/Chronology

Date Description
01- Dec 1997 EPA released the Mercury Study Report to Congress.
02- Oct 2000 EPA released a draft document titled, Reference Dose for Methylmercury (NCEA-S-0930)" for a 30-day public review and comment. Following the review an external peer-review workshop was held to review the document.
03- Jan 2001 EPA released the IRIS Summary for Methylmercury on the IRIS website and released the water quality criteria guidelines for states and authorized tribes.
04- Jan 2009 EPA released the Methylmercury Implementation Guidance.
05- Apr 2010 EPA released an update, referred to as the Methylmercury Implementation Guidance (Updated Apr 2010).
07- Apr 2019 EPA released the IRIS Assessment Plan (IAP) for Methylmercury for public comment and review. [Federal Register Notice Apr 4, 2019]
08- May 2019 EPA hosted a public science meeting to discuss preliminary meeting materials for methylmercury.

Status

Following the public (webinar) meeting, the IRIS Program will use the IAP to inform the subsequent development of a chemical-specific systematic review protocol.

Top of Page

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.




Federal Register Notices

Top of Page

Quick Check

Quick check is a visual indication of the current step that this IRIS assessment has started or is in.