Perfluorohexanesulfonic Acid (PFHxS)
CASRN 355-46-4 | DTXSID7040150
IRIS Toxicological Review of Perfluorohexanesulfonic Acid (PFHxS) and Related Salts (Public Comment and External Review Draft)
PFHxS is used in water- and stain-protective coatings for consumer products such as carpets, textiles, paper (including food-contact), packaging (including food-contact), textiles, and electronics. It has been used industrially as a surfactant to make fluoropolymers, as a surfactant or surface protection agent for cleaning and polishing products, and in other industrial fluids or water-proofing agents. It may also be present unintentionally as an impurity from industrial production processes. PFHxS has also been used in aqueous film-forming foam (AFFF) for fire suppression.
|Nov 2019||EPA released the Systematic Review Protocol for the PFHxS IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019]|
|Jul 2020||EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments.|
|Jan 2023||EPA sent an interagency science consultation PFHxS draft for review and comment.|
|Jul 2023||EPA released the draft IRIS Toxicological Review of Perfluorohexanesulfonic Acid (PFHxS) and Related Salts for a 60-day public comment period and external peer review. EPA also released the interagency science consultation comments from reviewers. [Federal Register Notice: July 24, 2023]|
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Document Related Link(s)
- Systematic Review Protocol for the PFAS IRIS Assessments (2021)
- Systematic Review Protocol for the Perfluorohexanesulfonic Acid (PFHxS) IRIS Assessment (Preliminary Assessment Materials)
- IRIS Toxicological Review of Perfluorohexanesulfonic Acid (PFHxS) and Related Salts (Interagency Science Consultation Draft, 2023)