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Perfluorononanoic Acid (PFNA)

CASRN 375-95-1 | DTXSID8031863

  • Status: perfluorononanoic acid (pfna) is in step 6 at this time.
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IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Interagency Science Consultation Draft, 2023)

On this page:

  • Overview
  • Background
  • Downloads

Overview

In March 2024, the draft IRIS Assessment of Perfluorononanoic Acid (PFNA) and Related Salts (Public Comment and External Review Draft) and the draft charge to external peer reviewers were released for a 60-day public review and comment period. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available on this site.

Background

Perfluorononanoic Acid (PFNA) and its related salts are members of the group of per and polyfluoroalkyl substances (PFAS). PFAS are not naturally occurring in the environment; they are man-made compounds that have been used widely over the past several decades in consumer products and industrial applications because of their resistance to heat, oil, stains, grease, and water. Concerns about PFNA and other PFAS stem from the resistance of these compounds to hydrolysis, photolysis, and biodegradation, which leads to their persistence in the environment.

PFNA has been used to make fluoropolymers, a coating that can resist heat, water, and chemicals; thus, PFNA can be present in products including carpets, food-contact papers, and cleaning and polishing products. Low levels of PFNA are detected in aqueous film-forming foam (AFFF) for fire suppression. PFNA is also a breakdown product of other PFAS (e.g. 8:2 fluorotelomer alcohol).

History/Chronology
Date Description
Nov 2019 EPA released the Systematic Review Protocol for the PFAS IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019]
Jul 2020 EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments.
Jul 2023 EPA sent an interagency science consultation PFNA draft for review and comment.
Mar 2024 EPA released the draft IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts for a 60-day public comment period and external peer review. The comments on the Interagency Science Consultation Draft were also released. [Federal Register Notice Mar 07, 2024 ]

Status

The Perfluorononanoic Acid (PFNA) and Related Salts IRIS assessment was released for public comment in March 2024. Following the public comment period, there will be an external peer review. The assessment will then be revised taking into consideration public and peer review comments.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • 1. ATSDR PFNA IASC Comments July 2023 (PDF)  (3  pp, 199.2 KB, about PDF)
  • 2. DoD PFNA IASC Comments July 2023 (PDF)  (30  pp, 373.0 KB, about PDF)
  • 3. DOE PFNA IASC Comments July 2023 (PDF)  (2  pp, 116.2 KB, about PDF)
  • 4. FDA PFNA IASC Comments July 2023 (PDF)  (2  pp, 129.9 KB, about PDF)
  • 5. NIEHS PFNA IASC Comments July 2023 (PDF)  (9  pp, 321.3 KB, about PDF)
  • 6. NIOSH PFNA IASC Comments July 2023 (PDF)  (1  pp, 140.6 KB, about PDF)
  • 7. USDA PFNA IASC Comments July 2023 (PDF)  (1  pp, 106.4 KB, about PDF)
  • 8. ATSDR PFNA IASC Hepatic Comments December 2023 (PDF)  (1  pp, 114.3 KB, about PDF)
  • 9. DoD PFNA IASC Appendix Comments December 2023 (PDF)  (4  pp, 85.0 KB, about PDF)
  • 10. DoD PFNA IASC Hepatic Comments December 2023 (PDF)  (3  pp, 85.9 KB, about PDF)
  • 11. NIEHS PFNA IASC Hepatic Comments December 2023 (PDF)  (1  pp, 148.4 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • Systematic Review Protocol for the PFAS IRIS Assessments (2021)
  • Systematic Review Protocol for the Perfluorononanoic Acid (PFNA) IRIS Assessment (Preliminary Assessment Materials)
  • IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Public Comment and External Review Draft)

Quick Check

Image text: 1. Draft Development, 2. Agency Review, 3. Interagency Science Consultation, 4. Public Comment and External Peer Review, 5. Revise Assessment, 6. (highlighted) Final Agency Review/Interagency Science Discussion, 7. Final Assessment

Related Links

  • EPA Chemicals Dashboard - Perfluorononanoic Acid (PFNA)

Chemical Structure for
Perfluorononanoic Acid (PFNA)

Perfluorononanoic Acid (PFNA)
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Last updated on April 24, 2024
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