Vanadium and Compounds (Inhalation)

CASRN Various

Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials)

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EPA announces the availability of the systematic review protocol for the vanadium and compounds (inhalation) IRIS Assessment for a 30-day public comment period. The deadline for comments is September 27, 2023.


In August 2023, EPA released the systematic review Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials). As part of developing a draft IRIS assessment, EPA presents a protocol that describes the methodology for how the assessment will be conducted, including systematic review and dose-response. These could include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.


U.S. EPA. Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-23/167, 2023.

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Vanadium is a transition metal that occurs naturally in Earth’s crust. Fossil fuel combustion is thought to be the major anthropogenic source of vanadium to the atmosphere. The use of heavy oils and bitumen from tar sands and the use of vanadium in industrial applications (e.g., steel production, vanadium redox-flow batteries, and catalytic converters) can contribute to the release of vanadium into the environment.


Date Description
01- May 2021 EPA released the IRIS Assessment Plan for inhalation exposure to vanadium and compounds for public comment and review. [Federal Register Notice May 28, 2021]
02- Jun 2021 EPA announced an extension of the public comment period until July 13, 2021. [Federal Register Notice Jun 25, 2021]
03- Aug 2023 EPA released the Systematic Review Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials) for public comment and review. [Federal Register Notice Aug 28, 2023 ]


The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.

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This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Federal Register Notices


Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2020-0182

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Quick Check

Quick check is a visual indication of the current step that this IRIS assessment has started or is in.