1,1,2,2-Tetrachloroethane

Overview

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 1,1,2,2-tetrachloroethane that will appear on the Integrated Risk Information System (IRIS) database.

Background

The draft Toxicological Review of 1,1,2,2-tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-tetrachloroethane. 1,1,2,2 Tetrachloroethane (1,1,2,2TCE; CASRN 79-34-5) is a synthetic halogenated hydrocarbon that is a colorless, nonflammable liquid at room temperature. The major use for 1,1,2,2 tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene. This assessment contains the derivation of both a subchronic and chronic reference dose and an oral cancer slope factor. EPA is also putting forth for external review the statement that the human carcinogenic potential of 1,1,2,2-tetrachloroethane is “likely to be carcinogenic to humans”.

History/Chronology

Date	Description
Mar 1987	An assessment for 1,1,2,2-tetrachloroethane is currently available on IRIS and contains a carcinogenicity assessment last revised in 1994.
2003	1,1,2,2-tetrachloroethane was nominated for reassessment by the Office of Air and Radiation/OAQPS and Region 4.
Sep 2009	EPA releases an external review draft of the assessment for public review and comment.
Dec 2009	EPA announces an external peer review workshop to be held on January 27, 2010 in a December 17, 2009 Federal Register Notice.
Feb 2010	EPA releases the comments from the public comment period and external review workshop.

Status

Following External Peer Review, the final assessment is scheduled to be posted to the IRIS database.

Additional Information

Comments on the assessment were submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2009-0115 (for the docket ID).

• IRIS Toxicological Review of 1,1,2,2-tetrachloroethane (External Review Draft) (PDF)  (194  pp, 1.8 MB, about PDF)
• Charge to External Peer Reviewers (PDF)  (2  pp, 20.5 KB, about PDF)
• Consolidated Comments from the External Peer Review (Final) (PDF)  (53  pp, 309.6 KB, about PDF)

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Federal Register Notices

• FR Notice: Dec 17, 2009
• FR Notice: Sep 24, 2009