Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock ( Lock A locked padlock ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

  • Environmental Topics
  • Laws & Regulations
  • Report a Violation
  • About EPA
IRIS
Contact Us

Trichloroacetic acid

CASRN 76-03-9 | DTXSID1021378

  • Toxicological Review (PDF)  (270  pp, 2.0 MB, about PDF)
  • IRIS Summary (PDF)  (26  pp, 266.6 KB, about PDF)
  • Key IRIS
    Values
  • Chemical
    Documents
  • Report
    Details
  • Other EPA
    Information

IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroacetic acid (TCA) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

Background

The draft Toxicological Review of trichloroacetic acid provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination.

This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.

History/Chronology
Date Description
Mar 1996 EPA posted the IRIS assessment for trichloroacetic acid on the IRIS database (cancer assessment only).
Sep 2009 EPA released an external review draft for public review and comment. A public listening session to discuss the report will be held on November 4, 2009.
Sep 2009 EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of Trichloroacetic Acid.
Nov 2009 EPA announces the details of an external peer review workshop to be held on December 10, 2009 in a November 10, 2009 Federal Register Notice.
Jan 2010 EPA releases the comments from the public comment period and external review workshop.

Status

Following external peer review of the report, the final assessment will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA-HQ-ORD-2009-0203 (for the docket ID).

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • Toxicological Review of Trichloroacetic Acid (External Review Draft) (PDF)  (253  pp, 1.2 MB, about PDF)
  • Charge to External Peer Reviewers (PDF)  (2  pp, 23.4 KB, about PDF)
  • Consolidated Comments from the External Peer Review (Final) (PDF)  (70  pp, 338.9 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Consultation Draft)
  • IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft)
  • IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Final Report)

Federal Register Notices

  • FR Notice: Nov 10, 2009
  • FR Notice: Sep 24, 2009

Related Links

  • EPA Chemicals Dashboard - Trichloroacetic acid
  • eChemPortal - Trichloroacetic acid

Critical Effect Systems

Hepatic
Hepatic

Tumor Sites

Hepatic
Hepatic

Chemical Structure for
Trichloroacetic acid

Trichloroacetic acid

Synonyms

  • AI3-24157
  • Acetic acid, trichloro-
  • Aceto-Caustin
  • Acide trichloracetique [French]
  • Acido tricloroacetico [Italian]
  • Acido tricloroacetico [Spanish]
  • Amchem Grass Killer
  • Caswell No. 870
  • EPA Pesticide Chemical Code 081002
  • HSDB 1779
  • Kyselina trichloroctova [Czech]
  • TCA
  • Trichloorazijnzuur [Dutch]
  • Trichloressigsaeure [German]
  • Trichloroacetic acid
  • Trichloroethanoic acid
  • 76-03-9
  • IRIS Home
  • About IRIS
  • IRIS Recent Additions
  • IRIS Calendar
  • IRIS Assessments
  • Advanced Search
  • IRIS Program Materials
Contact Us to ask a question, provide feedback, or report a problem.
Last updated on February 01, 2017
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshots
  • Grants
  • No FEAR Act Data
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data.gov
  • Inspector General
  • Jobs
  • Newsroom
  • Open Government
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions

Follow.