IRIS Toxicological Review of Naphthalene (2004, External Review Draft, Update)

IRIS

Naphthalene

CASRN 91-20-3 | DTXSID8020913

Toxicological Review (PDF) (116 pp, 551.8 KB)
IRIS Summary (PDF) (32 pp, 99.6 KB)
Status: naphthalene is in step 1 at this time.

On this page:

Overview
Background
Downloads

Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the Risk Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

[Update Jun 2004] This document contains revision of the inhalation cancer assessment and other selected text from the 1998 draft as indicated: Sections of this document pertaining to the inhalation cancer assessment are presented as draft for external peer review purposes only and do not constitute U.S. Environmental Protection Agency policy. These sections are indicated by highlighting. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. Note to reviewers: Please review the highlighted sections.

EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of naphthalene that when finalized will appear on the Integrated Risk Information System (IRIS) database.

Citation

U.S. EPA. IRIS Toxicological Review of Naphthalene (2004, External Review Draft, Update). U.S. Environmental Protection Agency, Washington, DC, NCEA-S-1707, 2004.

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Background

Naphthalene (CAS no. 91-20-3) is a bicyclic aromatic hydrocarbon with the chemical formula C10H8 and a molecular weight of 128.16. Pure naphthalene is a white, water-insoluble solid at room temperature with a vapor pressure of 0.087 mmHg (U.S. EPA, 1987; ATSDR,1993). Naphthalene is produced by distillation and fractionation of either petroleum or coal tar. Naphthalene’s principal use is as an intermediate in the production of phthalic anhydride. Phthalic anhydride is important in the manufacture of phthalate plasticizers, resins, dyes as well as insect and animal repellents. Naphthalene is also used in the manufacture of synthetic leather tanning agents and the insecticide carbaryl. Naphthalene has been used as a moth repellent and as a deodorizer for diaper pails and toilets (ATSDR, 1993; U.S. EPA, 1980, 1987).

Status

This draft has been archived.

Additional Information

EPA is hereby providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of naphthalene. These documents are provided for public viewing during an external scientific peer review period. Sections of the documents pertaining to the inhalation carcinogenicity of naphthalene are the subject of the external review. While EPA is not soliciting public comments by this action, any scientific views received on the content of the Toxicological Review or IRIS Summary prior to August 13, 2004 will be considered in subsequent drafts.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Toxicological Review of Naphthalene - Revised June 2004 - (Inhalation cancer assessment and other selected text, as indicated) (PDF) (129 pp, 522.5 KB, about PDF)
IRIS SUMMARY OF THE REASSESSMENT OF THE INHALATION CARCINOGENICITY OF NAPHTHALENE (EXTERNAL REVIEW DRAFT) (PDF) (28 pp, 195.3 KB, about PDF)
Charge to External Reviewers for the IRIS Reassessment of the Inhalation Carcinogenicity of Naphthalene June 2004 (PDF) (NA pp, 65.4 KB, about PDF)
Consolidated Comments from the External Peer Review (Final) (PDF) (30 pp, 215.8 KB, about PDF)

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Federal Register Notices

FR NOTICE: JUL 7, 2004

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US EPA

IRIS

Naphthalene

CASRN 91-20-3 | DTXSID8020913