1,4-Dioxane

CASRN 123-91-1 | DTXSID4020533

Toxicological Review (PDF) (419 pp, 3.5 MB, about PDF)
IRIS Summary (PDF) (32 pp, 284.2 KB, about PDF)

IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (Interagency Science Discussion Draft)

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Overview
Background
Downloads

Alert
Notice - This site contains archived material(s)

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Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

On September 9, 2011, the Toxicological Review of 1,4-Dioxane (inhalation) (External Review Draft) was posted for external peer review and public comment. Subsequently, the Toxicological Review and IRIS Summary were reviewed internally by EPA and by other federal agencies and Executive Office of the President before final public release. Based on the 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and the Executive Office of the President will be made publicly available. Accordingly, interagency comments with EPA's response and the interagency science discussion draft of the IRIS Toxicological Review of 1,4-dioxane (with inhalation update) and the draft IRIS Summary are posted on this site.

Background

1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coating, adhesive agent, and an ingredient in chemical manufacture. The IRIS Program completed the assessment for oral exposure to 1,4-dioxane on August 11, 2010 and noted that new inhalation studies would be evaluated separately. The 2010 oral assessment has now been updated with additional information regarding 1,4-dioxane toxicity following exposure via inhalation resulting in the 2013 1,4-dioxane assessment (with inhalation update).

History/Chronology
Date	Description
Aug 2010	EPA released the final oral toxicity assessment of 1,4-dioxane on the IRIS Web site.
May 2011	EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane.
Sep 2011	EPA released the external review draft of the 1,4-dioxane assessment (with inhalation update) for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.
Jul 2013	EPA initiated the final agency review and interagency science discussion on the draft Toxicological Review of 1,4-Dioxane (with inhalation update) and draft IRIS Summary.
Sep 2013	EPA released the final IRIS Toxicological Review of 1,4-Dioxane (with inhalation update) and IRIS Summary for 1,4-Dioxane along with the interagency science discussion draft, interagency comments, and EPA's response to interagency comments.

Status

This assessment has been loaded into the IRIS Website and Database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

IRIS Toxicological Review of 1,4-Dioxane (with inhalation update) (Interagency Science Discussion Draft) (Jun 2013) (PDF) (364 pp, 3.8 MB, about PDF)
IRIS Summary for 1,4-Dioxane (with inhalation update) (Interagency Science Discussion Draft) (Jun 2013) (PDF) (26 pp, 238.3 KB, about PDF)
EPA’s Response to Major Interagency Science Discussion Comments (PDF) (4 pp, 56.6 KB, about PDF)
1. CDC ATSDR Comments on 1,4-dioxane(with inhalation update) (PDF) (2 pp, 50.8 KB, about PDF)
2. CEQ IASD Comments on 1,4-dioxane(with inhalation update) (PDF) (1 pp, 39.1 KB, about PDF)
3. DoD IASD Comments on 1,4-dioxane Tox Review (with inhalation update) (PDF) (7 pp, 72.3 KB, about PDF)
4. DoD IASD Comments on 1,4-dioxane IRIS Summary (with inhalation update) (PDF) (2 pp, 48.8 KB, about PDF)
5. NIOSH IASD Comments on 1,4-dioxane (with inhalation update) (PDF) (2 pp, 46.9 KB, about PDF)
6. OMB and OSTP IASD Comments on 1,4-dioxane (with inhalation update) (PDF) (1 pp, 47.9 KB, about PDF)

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