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Ethylbenzene

CASRN 100-41-4 | DTXSID3020596

  • IRIS Summary (PDF)  (21  pp, 144.5 KB, about PDF)
  • Status: ethylbenzene is in step 1 at this time.
  • Key IRIS
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Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice

EPA announced the release of the Protocol for the Ethylbenzene IRIS Assessment for a 30-day public comment period as announced in a February 17, 2023 Federal Register Notice. The deadline for comments was March 17, 2023.

Overview

In February 2023, EPA released the Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials) for a 30-day public review and comment period. As part of developing a draft IRIS assessment, EPA presents a protocol that describes the methodology for how the assessment will be conducted, including systematic review and dose-response. These could include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

Background

Ethylbenzene is a colorless, flammable liquid with a sweet, gasoline-like odor. It is naturally found in products such as coal tar and crude petroleum. Ethylbenzene is primarily used as a chemical intermediate to produce styrene. In smaller quantities, ethylbenzene is also used as a solvent in common products like rubber, inks, insecticides, paints, and in fuels.

History/Chronology
Date Description
Sep 2017 EPA released the IRIS Assessment Plan (IAP) for Ethylbenzene for public comment and review. [Federal Register Notice Sep 18, 2017]
Feb 2023 EPA released the Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice February 17, 2023]

Status

The IRIS Program will use the protocol to develop the draft assessment.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials) (PDF)  (140  pp, 2.5 MB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Assessment Plan for Ethylbenzene (Scoping and Problem Formulation Materials)

HERO Project

  • Literature Search References Sorted by Author (Ethylbenzene)

Federal Register Notices

  • FR Notice: Feb 17 2023

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2014-0526

Quick Check

Image text: 1. (highlighted) Draft Development, 2. Agency Review, 3. Interagency Science Consultation, 4. Public Comment and External Peer Review, 5. Revise Assessment, 6. Final Agency Review/Interagency Science Discussion, 7. Final Assessment

Related Links

  • EPA Chemicals Dashboard - Ethylbenzene
  • eChemPortal - Ethylbenzene

Critical Effect Systems

Developmental
Developmental

Hepatic
Hepatic

Urinary
Urinary

Chemical Structure for
Ethylbenzene

Ethylbenzene

Synonyms

  • Aethylbenzol
  • Benzene, ethyl
  • EB
  • Ethylbenzeen
  • Ethylbenzene
  • Ethylbenzol
  • Etilbenzene
  • Etylobenzen
  • NCI-C56393
  • Phenylethane
  • UN 1175
  • 100-41-4
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Last updated on April 11, 2023
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